204736

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 241105..241747 Replicon chromosome
Accession NZ_CP076187
Organism Bacillus anthracis str. BF1

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag KM400_RS01335 Protein ID WP_000635963.1
Coordinates 241397..241747 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag KM400_RS01330 Protein ID WP_000004570.1
Coordinates 241105..241392 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM400_RS01305 (KM400_01305) 236421..237383 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
KM400_RS01310 (KM400_01310) 237376..237948 - 573 WP_000906915.1 rhomboid family intramembrane serine protease -
KM400_RS01315 (KM400_01315) 238041..238400 + 360 WP_000635040.1 holo-ACP synthase -
KM400_RS01320 (KM400_01320) 238557..239507 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
KM400_RS01325 (KM400_01325) 239626..240795 + 1170 WP_000390596.1 alanine racemase -
KM400_RS01330 (KM400_01330) 241105..241392 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
KM400_RS01335 (KM400_01335) 241397..241747 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
KM400_RS01340 (KM400_01340) 241815..243983 + 2169 WP_000426225.1 Tex family protein -
KM400_RS01345 (KM400_01345) 244041..244157 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
KM400_RS01350 (KM400_01350) 244353..244811 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T204736 WP_000635963.1 NZ_CP076187:241397-241747 [Bacillus anthracis str. BF1]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T204736 NZ_CP101233:c2318560-2318384 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT204736 WP_000004570.1 NZ_CP076187:241105-241392 [Bacillus anthracis str. BF1]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT204736 NZ_CP101233:c2318338-2317922 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References