Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2311628..2312603 Replicon chromosome
Accession NZ_CP076184
Organism Bacillus anthracis strain A49

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag JNO61_RS12100 Protein ID WP_002036394.1
Coordinates 2311628..2312365 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag JNO61_RS12105 Protein ID WP_000588712.1
Coordinates 2312478..2312603 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNO61_RS12080 (JNO61_12075) 2307356..2308138 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
JNO61_RS12085 (JNO61_12080) 2308260..2309945 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
JNO61_RS12090 (JNO61_12085) 2310052..2310534 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
JNO61_RS12095 (JNO61_12090) 2310702..2311439 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
JNO61_RS12100 (JNO61_12095) 2311628..2312365 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
JNO61_RS12105 (JNO61_12100) 2312478..2312603 + 126 WP_000588712.1 hypothetical protein Antitoxin
JNO61_RS12110 (JNO61_12105) 2312626..2312856 + 231 WP_011053163.1 stage II sporulation protein SB -
JNO61_RS12115 (JNO61_12110) 2312893..2313174 - 282 WP_001041555.1 hypothetical protein -
JNO61_RS12120 (JNO61_12115) 2313451..2313687 - 237 WP_001021689.1 hypothetical protein -
JNO61_RS28690 2313824..2313949 + 126 WP_000694311.1 hypothetical protein -
JNO61_RS12125 (JNO61_12120) 2314026..2314202 + 177 WP_000808045.1 stage II sporulation protein SB -
JNO61_RS12130 (JNO61_12125) 2314346..2315815 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
JNO61_RS12135 (JNO61_12130) 2316379..2316849 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204735 WP_002036394.1 NZ_CP076184:2311628-2312365 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204735 NZ_CP101233:2209457-2210779 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204735 WP_000588712.1 NZ_CP076184:2312478-2312603 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204735 NZ_CP101233:2209191-2209457 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References