Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2317066..2318041 Replicon chromosome
Accession NZ_CP076181
Organism Bacillus anthracis strain A27

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM408_RS12120 Protein ID WP_002036394.1
Coordinates 2317066..2317803 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM408_RS12125 Protein ID WP_000588712.1
Coordinates 2317916..2318041 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM408_RS12100 (KM408_12095) 2312794..2313576 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM408_RS12105 (KM408_12100) 2313698..2315383 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM408_RS12110 (KM408_12105) 2315490..2315972 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM408_RS12115 (KM408_12110) 2316140..2316877 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM408_RS12120 (KM408_12115) 2317066..2317803 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM408_RS12125 (KM408_12120) 2317916..2318041 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM408_RS12130 (KM408_12125) 2318064..2318294 + 231 WP_011053163.1 stage II sporulation protein SB -
KM408_RS12135 (KM408_12130) 2318331..2318612 - 282 WP_001041555.1 hypothetical protein -
KM408_RS12140 (KM408_12135) 2318889..2319125 - 237 WP_001021689.1 hypothetical protein -
KM408_RS28820 2319262..2319387 + 126 WP_000694311.1 hypothetical protein -
KM408_RS12145 (KM408_12140) 2319464..2319640 + 177 WP_000808045.1 stage II sporulation protein SB -
KM408_RS12150 (KM408_12145) 2319784..2321253 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM408_RS12155 (KM408_12150) 2321817..2322287 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204733 WP_002036394.1 NZ_CP076181:2317066-2317803 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204733 NZ_CP101233:937075-937410 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204733 WP_000588712.1 NZ_CP076181:2317916-2318041 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204733 NZ_CP101233:936827-937075 [Escherichia coli]
ATGATCCACAGTAGTGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References