Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316880..2317855 Replicon chromosome
Accession NZ_CP076178
Organism Bacillus anthracis strain BUL 12

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM402_RS12105 Protein ID WP_002036394.1
Coordinates 2316880..2317617 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM402_RS12110 Protein ID WP_000588712.1
Coordinates 2317730..2317855 (+) Length 42 a.a.

Genomic Context

KM402_RS12085KM402_RS12095KM402_RS12100KM402_RS12105KM402_RS12110KM402_RS12115KM402_RS28750KM402_RS12130KM402_RS12135KM402_RS12090KM402_RS12120KM402_RS12125KM402_RS12140
Location: 2312608..2313390 (783 bp)
Type: Others
Protein ID: WP_000381787.1
Location: 2315304..2315786 (483 bp)
Type: Others
Protein ID: WP_000191911.1
Location: 2315954..2316691 (738 bp)
Type: Others
Protein ID: WP_000594139.1
Location: 2316880..2317617 (738 bp)
Type: Toxin
Protein ID: WP_002036394.1
Location: 2317730..2317855 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 2317878..2318108 (231 bp)
Type: Others
Protein ID: WP_011053163.1
Location: 2319076..2319201 (126 bp)
Type: Others
Protein ID: WP_000694311.1
Location: 2319278..2319454 (177 bp)
Type: Others
Protein ID: WP_000808045.1
Location: 2319598..2321067 (1470 bp)
Type: Others
Protein ID: WP_000287522.1
Location: 2313512..2315197 (1686 bp)
Type: Others
Protein ID: WP_014654562.1
Location: 2318145..2318426 (282 bp)
Type: Others
Protein ID: WP_001041555.1
Location: 2318703..2318939 (237 bp)
Type: Others
Protein ID: WP_001021689.1
Location: 2321631..2322101 (471 bp)
Type: Others
Protein ID: WP_000670597.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KM402_RS12085 (KM402_12095)2312608..2313390+783WP_000381787.1class I SAM-dependent methyltransferase-
KM402_RS12090 (KM402_12100)2313512..2315197-1686WP_014654562.1alpha-keto acid decarboxylase family protein-
KM402_RS12095 (KM402_12105)2315304..2315786+483WP_000191911.1MarR family winged helix-turn-helix transcriptional regulator-
KM402_RS12100 (KM402_12110)2315954..2316691+738WP_000594139.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
KM402_RS12105 (KM402_12115)2316880..2317617+738WP_002036394.1type II toxin-antitoxin system SpoIISA family toxinToxin
KM402_RS12110 (KM402_12120)2317730..2317855+126WP_000588712.1hypothetical proteinAntitoxin
KM402_RS12115 (KM402_12125)2317878..2318108+231WP_011053163.1stage II sporulation protein SB-
KM402_RS12120 (KM402_12130)2318145..2318426-282WP_001041555.1hypothetical protein-
KM402_RS12125 (KM402_12135)2318703..2318939-237WP_001021689.1hypothetical protein-
KM402_RS287502319076..2319201+126WP_000694311.1hypothetical protein-
KM402_RS12130 (KM402_12140)2319278..2319454+177WP_000808045.1stage II sporulation protein SB-
KM402_RS12135 (KM402_12145)2319598..2321067+1470WP_000287522.1beta-Ala-His dipeptidase-
KM402_RS12140 (KM402_12150)2321631..2322101-471WP_000670597.1DUF5065 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204731 WP_002036394.1 NZ_CP076178:2316880-2317617 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204731 NZ_CP101233:735136-735432 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204731 WP_000588712.1 NZ_CP076178:2317730-2317855 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204731 NZ_CP101233:735434-735829 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2R2IKP2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References