Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316876..2317851 Replicon chromosome
Accession NZ_CP076176
Organism Bacillus anthracis strain BUL 32

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM407_RS12100 Protein ID WP_002036394.1
Coordinates 2316876..2317613 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM407_RS12105 Protein ID WP_000588712.1
Coordinates 2317726..2317851 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM407_RS12080 (KM407_12090) 2312604..2313386 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM407_RS12085 (KM407_12095) 2313508..2315193 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM407_RS12090 (KM407_12100) 2315300..2315782 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM407_RS12095 (KM407_12105) 2315950..2316687 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM407_RS12100 (KM407_12110) 2316876..2317613 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM407_RS12105 (KM407_12115) 2317726..2317851 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM407_RS12110 (KM407_12120) 2317874..2318104 + 231 WP_011053163.1 stage II sporulation protein SB -
KM407_RS12115 (KM407_12125) 2318141..2318422 - 282 WP_001041555.1 hypothetical protein -
KM407_RS12120 (KM407_12130) 2318699..2318935 - 237 WP_001021689.1 hypothetical protein -
KM407_RS27890 2319072..2319197 + 126 WP_000694311.1 hypothetical protein -
KM407_RS12125 (KM407_12135) 2319274..2319450 + 177 WP_000808045.1 stage II sporulation protein SB -
KM407_RS12130 (KM407_12140) 2319594..2321063 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM407_RS12135 (KM407_12145) 2321627..2322097 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204729 WP_002036394.1 NZ_CP076176:2316876-2317613 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204729 NZ_CP101233:c619103-618639 [Escherichia coli]
ATGGATTTTCTACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204729 WP_000588712.1 NZ_CP076176:2317726-2317851 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204729 NZ_CP101233:c619438-619103 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTAGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References