Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316958..2317933 Replicon chromosome
Accession NZ_CP076170
Organism Bacillus anthracis strain A168

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM414_RS12115 Protein ID WP_002036394.1
Coordinates 2316958..2317695 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM414_RS12120 Protein ID WP_000588712.1
Coordinates 2317808..2317933 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM414_RS12095 (KM414_12085) 2312686..2313468 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM414_RS12100 (KM414_12090) 2313590..2315275 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM414_RS12105 (KM414_12095) 2315382..2315864 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM414_RS12110 (KM414_12100) 2316032..2316769 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM414_RS12115 (KM414_12105) 2316958..2317695 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM414_RS12120 (KM414_12110) 2317808..2317933 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM414_RS12125 (KM414_12115) 2317956..2318186 + 231 WP_011053163.1 stage II sporulation protein SB -
KM414_RS12130 (KM414_12120) 2318223..2318504 - 282 WP_001041555.1 hypothetical protein -
KM414_RS12135 (KM414_12125) 2318781..2319017 - 237 WP_001021689.1 hypothetical protein -
KM414_RS28815 2319154..2319279 + 126 WP_000694311.1 hypothetical protein -
KM414_RS12140 (KM414_12130) 2319356..2319532 + 177 WP_000808045.1 stage II sporulation protein SB -
KM414_RS12145 (KM414_12135) 2319676..2321145 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM414_RS12150 (KM414_12140) 2321709..2322179 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204725 WP_002036394.1 NZ_CP076170:2316958-2317695 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204725 NZ_CP101224:c87654-87124 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTAATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204725 WP_000588712.1 NZ_CP076170:2317808-2317933 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204725 NZ_CP101224:c87927-87658 [Escherichia coli]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAAACTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References