Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316957..2317932 Replicon chromosome
Accession NZ_CP076164
Organism Bacillus anthracis strain A193a

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM415_RS12100 Protein ID WP_002036394.1
Coordinates 2316957..2317694 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM415_RS12105 Protein ID WP_000588712.1
Coordinates 2317807..2317932 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM415_RS12080 (KM415_12080) 2312685..2313467 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM415_RS12085 (KM415_12085) 2313589..2315274 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM415_RS12090 (KM415_12090) 2315381..2315863 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM415_RS12095 (KM415_12095) 2316031..2316768 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM415_RS12100 (KM415_12100) 2316957..2317694 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM415_RS12105 (KM415_12105) 2317807..2317932 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM415_RS12110 (KM415_12110) 2317955..2318185 + 231 WP_011053163.1 stage II sporulation protein SB -
KM415_RS12115 (KM415_12115) 2318222..2318503 - 282 WP_001041555.1 hypothetical protein -
KM415_RS12120 (KM415_12120) 2318780..2319016 - 237 WP_001021689.1 hypothetical protein -
KM415_RS28750 2319153..2319278 + 126 WP_000694311.1 hypothetical protein -
KM415_RS12125 (KM415_12125) 2319355..2319531 + 177 WP_000808045.1 stage II sporulation protein SB -
KM415_RS12130 (KM415_12130) 2319675..2321144 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM415_RS12135 (KM415_12135) 2321708..2322178 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204721 WP_002036394.1 NZ_CP076164:2316957-2317694 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204721 NZ_CP101222:5131267-5131578 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204721 WP_000588712.1 NZ_CP076164:2317807-2317932 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204721 NZ_CP101222:5131579-5131869 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References