Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /SpoIISA(toxin) |
Location | 2317107..2318082 | Replicon | chromosome |
Accession | NZ_CP076160 | ||
Organism | Bacillus anthracis strain 4-IZSLT |
Toxin (Protein)
Gene name | spoIISA | Uniprot ID | A0A2R2IKP2 |
Locus tag | KM412_RS12100 | Protein ID | WP_002036394.1 |
Coordinates | 2317107..2317844 (+) | Length | 246 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | R8HWP4 |
Locus tag | KM412_RS12105 | Protein ID | WP_000588712.1 |
Coordinates | 2317957..2318082 (+) | Length | 42 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KM412_RS12080 (KM412_12085) | 2312835..2313617 | + | 783 | WP_000381787.1 | class I SAM-dependent methyltransferase | - |
KM412_RS12085 (KM412_12090) | 2313739..2315424 | - | 1686 | WP_014654562.1 | alpha-keto acid decarboxylase family protein | - |
KM412_RS12090 (KM412_12095) | 2315531..2316013 | + | 483 | WP_000191911.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
KM412_RS12095 (KM412_12100) | 2316181..2316918 | + | 738 | WP_000594139.1 | 2,3-diphosphoglycerate-dependent phosphoglycerate mutase | - |
KM412_RS12100 (KM412_12105) | 2317107..2317844 | + | 738 | WP_002036394.1 | type II toxin-antitoxin system SpoIISA family toxin | Toxin |
KM412_RS12105 (KM412_12110) | 2317957..2318082 | + | 126 | WP_000588712.1 | hypothetical protein | Antitoxin |
KM412_RS12110 (KM412_12115) | 2318105..2318335 | + | 231 | WP_011053163.1 | stage II sporulation protein SB | - |
KM412_RS12115 (KM412_12120) | 2318372..2318653 | - | 282 | WP_001041555.1 | hypothetical protein | - |
KM412_RS12120 (KM412_12125) | 2318930..2319166 | - | 237 | WP_001021689.1 | hypothetical protein | - |
KM412_RS28755 | 2319303..2319428 | + | 126 | WP_000694311.1 | hypothetical protein | - |
KM412_RS12125 (KM412_12130) | 2319505..2319681 | + | 177 | WP_000808045.1 | stage II sporulation protein SB | - |
KM412_RS12130 (KM412_12135) | 2319825..2321294 | + | 1470 | WP_000287522.1 | beta-Ala-His dipeptidase | - |
KM412_RS12135 (KM412_12140) | 2321858..2322328 | - | 471 | WP_000670597.1 | DUF5065 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 246 a.a. Molecular weight: 28373.03 Da Isoelectric Point: 8.2705
>T204717 WP_002036394.1 NZ_CP076160:2317107-2317844 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK
Download Length: 738 bp
>T204717 NZ_CP101222:c4711031-4710924 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 42 a.a. Molecular weight: 4938.34 Da Isoelectric Point: 3.9150
>AT204717 WP_000588712.1 NZ_CP076160:2317957-2318082 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK
Download Length: 126 bp
>AT204717 NZ_CP101222:4711079-4711145 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2R2IKP2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A366GQT1 |