Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316959..2317934 Replicon chromosome
Accession NZ_CP076157
Organism Bacillus anthracis strain A87

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM410_RS12120 Protein ID WP_002036394.1
Coordinates 2316959..2317696 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM410_RS12125 Protein ID WP_000588712.1
Coordinates 2317809..2317934 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM410_RS12100 (KM410_12095) 2312687..2313469 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM410_RS12105 (KM410_12100) 2313591..2315276 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM410_RS12110 (KM410_12105) 2315383..2315865 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM410_RS12115 (KM410_12110) 2316033..2316770 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM410_RS12120 (KM410_12115) 2316959..2317696 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM410_RS12125 (KM410_12120) 2317809..2317934 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM410_RS12130 (KM410_12125) 2317957..2318187 + 231 WP_011053163.1 stage II sporulation protein SB -
KM410_RS12135 (KM410_12130) 2318224..2318505 - 282 WP_001041555.1 hypothetical protein -
KM410_RS12140 (KM410_12135) 2318782..2319018 - 237 WP_001021689.1 hypothetical protein -
KM410_RS28825 2319155..2319280 + 126 WP_000694311.1 hypothetical protein -
KM410_RS12145 (KM410_12140) 2319357..2319533 + 177 WP_000808045.1 stage II sporulation protein SB -
KM410_RS12150 (KM410_12145) 2319677..2321146 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM410_RS12155 (KM410_12150) 2321710..2322180 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204715 WP_002036394.1 NZ_CP076157:2316959-2317696 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204715 NZ_CP101222:c4168740-4168444 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204715 WP_000588712.1 NZ_CP076157:2317809-2317934 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204715 NZ_CP101222:c4168442-4168047 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References