Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316796..2317771 Replicon chromosome
Accession NZ_CP076151
Organism Bacillus anthracis strain BUL 31

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM406_RS12110 Protein ID WP_002036394.1
Coordinates 2316796..2317533 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM406_RS12115 Protein ID WP_000588712.1
Coordinates 2317646..2317771 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM406_RS12090 (KM406_12095) 2312524..2313306 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM406_RS12095 (KM406_12100) 2313428..2315113 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM406_RS12100 (KM406_12105) 2315220..2315702 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM406_RS12105 (KM406_12110) 2315870..2316607 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM406_RS12110 (KM406_12115) 2316796..2317533 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM406_RS12115 (KM406_12120) 2317646..2317771 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM406_RS12120 (KM406_12125) 2317794..2318024 + 231 WP_011053163.1 stage II sporulation protein SB -
KM406_RS12125 (KM406_12130) 2318061..2318342 - 282 WP_001041555.1 hypothetical protein -
KM406_RS12130 (KM406_12135) 2318619..2318855 - 237 WP_001021689.1 hypothetical protein -
KM406_RS28755 2318992..2319117 + 126 WP_000694311.1 hypothetical protein -
KM406_RS12135 (KM406_12140) 2319194..2319370 + 177 WP_000808045.1 stage II sporulation protein SB -
KM406_RS12140 (KM406_12145) 2319514..2320983 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM406_RS12145 (KM406_12150) 2321547..2322017 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204711 WP_002036394.1 NZ_CP076151:2316796-2317533 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204711 NZ_CP101222:c3730220-3729909 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCTAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204711 WP_000588712.1 NZ_CP076151:2317646-2317771 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204711 NZ_CP101222:c3729912-3729493 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCCTTACTTCGTACGCTGATTGATCAACATAATTTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
TCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCATATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References