Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2317105..2318080 Replicon chromosome
Accession NZ_CP076146
Organism Bacillus anthracis strain BUL 40

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM401_RS12110 Protein ID WP_002036394.1
Coordinates 2317105..2317842 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM401_RS12115 Protein ID WP_000588712.1
Coordinates 2317955..2318080 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM401_RS12090 (KM401_12085) 2312833..2313615 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM401_RS12095 (KM401_12090) 2313737..2315422 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM401_RS12100 (KM401_12095) 2315529..2316011 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM401_RS12105 (KM401_12100) 2316179..2316916 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM401_RS12110 (KM401_12105) 2317105..2317842 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM401_RS12115 (KM401_12110) 2317955..2318080 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM401_RS12120 (KM401_12115) 2318103..2318333 + 231 WP_011053163.1 stage II sporulation protein SB -
KM401_RS12125 (KM401_12120) 2318370..2318651 - 282 WP_001041555.1 hypothetical protein -
KM401_RS12130 (KM401_12125) 2318928..2319164 - 237 WP_001021689.1 hypothetical protein -
KM401_RS27950 2319301..2319426 + 126 WP_000694311.1 hypothetical protein -
KM401_RS12135 (KM401_12130) 2319503..2319679 + 177 WP_000808045.1 stage II sporulation protein SB -
KM401_RS12140 (KM401_12135) 2319823..2321292 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM401_RS12145 (KM401_12140) 2321856..2322326 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204707 WP_002036394.1 NZ_CP076146:2317105-2317842 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204707 NZ_CP101222:c2038944-2038837 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204707 WP_000588712.1 NZ_CP076146:2317955-2318080 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204707 NZ_CP101222:2038991-2039057 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References