Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2316995..2317970 Replicon chromosome
Accession NZ_CP076141
Organism Bacillus anthracis strain A29

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM409_RS12100 Protein ID WP_002036394.1
Coordinates 2316995..2317732 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM409_RS12105 Protein ID WP_000588712.1
Coordinates 2317845..2317970 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM409_RS12080 (KM409_12080) 2312723..2313505 + 783 WP_000381787.1 class I SAM-dependent methyltransferase -
KM409_RS12085 (KM409_12085) 2313627..2315312 - 1686 WP_014654562.1 alpha-keto acid decarboxylase family protein -
KM409_RS12090 (KM409_12090) 2315419..2315901 + 483 WP_000191911.1 MarR family winged helix-turn-helix transcriptional regulator -
KM409_RS12095 (KM409_12095) 2316069..2316806 + 738 WP_000594139.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
KM409_RS12100 (KM409_12100) 2316995..2317732 + 738 WP_002036394.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
KM409_RS12105 (KM409_12105) 2317845..2317970 + 126 WP_000588712.1 hypothetical protein Antitoxin
KM409_RS12110 (KM409_12110) 2317993..2318223 + 231 WP_011053163.1 stage II sporulation protein SB -
KM409_RS12115 (KM409_12115) 2318260..2318541 - 282 WP_001041555.1 hypothetical protein -
KM409_RS12120 (KM409_12120) 2318818..2319054 - 237 WP_001021689.1 hypothetical protein -
KM409_RS28755 2319191..2319316 + 126 WP_000694311.1 hypothetical protein -
KM409_RS12125 (KM409_12125) 2319393..2319569 + 177 WP_000808045.1 stage II sporulation protein SB -
KM409_RS12130 (KM409_12130) 2319713..2321182 + 1470 WP_000287522.1 beta-Ala-His dipeptidase -
KM409_RS12135 (KM409_12135) 2321746..2322216 - 471 WP_000670597.1 DUF5065 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204703 WP_002036394.1 NZ_CP076141:2316995-2317732 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204703 NZ_CP101222:c1190256-1190038 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204703 WP_000588712.1 NZ_CP076141:2317845-2317970 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204703 NZ_CP101222:c1190656-1190282 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2R2IKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References