Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2317034..2318009 Replicon chromosome
Accession NZ_CP076138
Organism Bacillus anthracis strain A182

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A2R2IKP2
Locus tag KM416_RS12095 Protein ID WP_002036394.1
Coordinates 2317034..2317771 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag KM416_RS12100 Protein ID WP_000588712.1
Coordinates 2317884..2318009 (+) Length 42 a.a.

Genomic Context

KM416_RS12075KM416_RS12085KM416_RS12090KM416_RS12095KM416_RS12100KM416_RS12105KM416_RS28755KM416_RS12120KM416_RS12125KM416_RS12080KM416_RS12110KM416_RS12115KM416_RS12130
Location: 2312762..2313544 (783 bp)
Type: Others
Protein ID: WP_000381787.1
Location: 2315458..2315940 (483 bp)
Type: Others
Protein ID: WP_000191911.1
Location: 2316108..2316845 (738 bp)
Type: Others
Protein ID: WP_000594139.1
Location: 2317034..2317771 (738 bp)
Type: Toxin
Protein ID: WP_002036394.1
Location: 2317884..2318009 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 2318032..2318262 (231 bp)
Type: Others
Protein ID: WP_011053163.1
Location: 2319230..2319355 (126 bp)
Type: Others
Protein ID: WP_000694311.1
Location: 2319432..2319608 (177 bp)
Type: Others
Protein ID: WP_000808045.1
Location: 2319752..2321221 (1470 bp)
Type: Others
Protein ID: WP_000287522.1
Location: 2313666..2315351 (1686 bp)
Type: Others
Protein ID: WP_014654562.1
Location: 2318299..2318580 (282 bp)
Type: Others
Protein ID: WP_001041555.1
Location: 2318857..2319093 (237 bp)
Type: Others
Protein ID: WP_001021689.1
Location: 2321785..2322255 (471 bp)
Type: Others
Protein ID: WP_000670597.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KM416_RS12075 (KM416_12080)2312762..2313544+783WP_000381787.1class I SAM-dependent methyltransferase-
KM416_RS12080 (KM416_12085)2313666..2315351-1686WP_014654562.1alpha-keto acid decarboxylase family protein-
KM416_RS12085 (KM416_12090)2315458..2315940+483WP_000191911.1MarR family winged helix-turn-helix transcriptional regulator-
KM416_RS12090 (KM416_12095)2316108..2316845+738WP_000594139.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
KM416_RS12095 (KM416_12100)2317034..2317771+738WP_002036394.1type II toxin-antitoxin system SpoIISA family toxinToxin
KM416_RS12100 (KM416_12105)2317884..2318009+126WP_000588712.1hypothetical proteinAntitoxin
KM416_RS12105 (KM416_12110)2318032..2318262+231WP_011053163.1stage II sporulation protein SB-
KM416_RS12110 (KM416_12115)2318299..2318580-282WP_001041555.1hypothetical protein-
KM416_RS12115 (KM416_12120)2318857..2319093-237WP_001021689.1hypothetical protein-
KM416_RS287552319230..2319355+126WP_000694311.1hypothetical protein-
KM416_RS12120 (KM416_12125)2319432..2319608+177WP_000808045.1stage II sporulation protein SB-
KM416_RS12125 (KM416_12130)2319752..2321221+1470WP_000287522.1beta-Ala-His dipeptidase-
KM416_RS12130 (KM416_12135)2321785..2322255-471WP_000670597.1DUF5065 family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28373.03 Da        Isoelectric Point: 8.2705

>T204701 WP_002036394.1 NZ_CP076138:2317034-2317771 [Bacillus anthracis]
VISNIRIGLFILAIVFLVLVFFYWRNEELYEEKKQRIRKTWYGLFIVSVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T204701 NZ_CP101222:923777-924175 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT204701 WP_000588712.1 NZ_CP076138:2317884-2318009 [Bacillus anthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT204701 NZ_CP101222:923481-923774 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2R2IKP2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References