Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4793751..4794313 Replicon chromosome
Accession NZ_CP076135
Organism Bradyrhizobium sediminis strain S2-11-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KMZ68_RS22925 Protein ID WP_215613406.1
Coordinates 4793751..4794122 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KMZ68_RS22930 Protein ID WP_215603616.1
Coordinates 4794122..4794313 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ68_RS22885 (KMZ68_22885) 4788781..4788936 + 156 WP_215613398.1 hypothetical protein -
KMZ68_RS22890 (KMZ68_22890) 4788946..4789332 + 387 WP_215613399.1 DUF971 domain-containing protein -
KMZ68_RS22895 (KMZ68_22895) 4789414..4790727 + 1314 WP_215613400.1 c-type cytochrome -
KMZ68_RS22900 (KMZ68_22900) 4790738..4791400 - 663 WP_215613401.1 TetR/AcrR family transcriptional regulator -
KMZ68_RS22905 (KMZ68_22905) 4791497..4792141 + 645 WP_215613402.1 glutathione binding-like protein -
KMZ68_RS22910 (KMZ68_22910) 4792180..4792746 - 567 WP_215613403.1 TetR/AcrR family transcriptional regulator -
KMZ68_RS22915 (KMZ68_22915) 4792755..4793222 - 468 WP_215613404.1 nuclear transport factor 2 family protein -
KMZ68_RS22920 (KMZ68_22920) 4793296..4793745 - 450 WP_215613405.1 tol-pal system-associated acyl-CoA thioesterase -
KMZ68_RS22925 (KMZ68_22925) 4793751..4794122 - 372 WP_215613406.1 PIN domain-containing protein Toxin
KMZ68_RS22930 (KMZ68_22930) 4794122..4794313 - 192 WP_215603616.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KMZ68_RS22935 (KMZ68_22935) 4794398..4795315 - 918 WP_215613407.1 metallophosphoesterase -
KMZ68_RS22940 (KMZ68_22940) 4795412..4796461 - 1050 WP_215613408.1 Holliday junction branch migration DNA helicase RuvB -
KMZ68_RS22945 (KMZ68_22945) 4796646..4797263 - 618 WP_215613409.1 Holliday junction branch migration protein RuvA -
KMZ68_RS22950 (KMZ68_22950) 4797260..4797787 - 528 WP_215613410.1 crossover junction endodeoxyribonuclease RuvC -
KMZ68_RS22955 (KMZ68_22955) 4797931..4798677 - 747 WP_215613411.1 YebC/PmpR family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13525.71 Da        Isoelectric Point: 5.1450

>T204694 WP_215613406.1 NZ_CP076135:c4794122-4793751 [Bradyrhizobium sediminis]
MVLADTSIWIDHFRRGDFQLSELLERGDIVIHPFIVGELLLGHVPRIAEMLDDLNVLPRAIVASAEEVLKFISDRKLPGS
GIGYVDAHLLAAAALTPETSVWTRDKRLLAAAQALSLATKFPE

Download         Length: 372 bp

>T204694 NZ_CP101212:72923-73321 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7089.22 Da        Isoelectric Point: 11.1982

>AT204694 WP_215603616.1 NZ_CP076135:c4794313-4794122 [Bradyrhizobium sediminis]
MRTTIAIDDELFAKAQEFAGVTEKSAVIREALKAFVEREAARRLARMGGTQPEAKAPPRRRFK

Download         Length: 192 bp

>AT204694 NZ_CP101212:72696-72923 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References