Detailed information of TA system TA204693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2505289..2505881
• Replicon: chromosome
• Accession: NZ_CP076135
• Organism: Bradyrhizobium sediminis strain S2-11-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KMZ68_RS11890
• Protein ID: WP_215615945.1
• Coordinates: 2505289..2505477 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KMZ68_RS11895
• Protein ID: WP_215615946.1
• Coordinates: 2505483..2505881 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KMZ68_RS11870 (KMZ68_11870)	2500352..2501092	-	741	WP_215615941.1	SDR family NAD(P)-dependent oxidoreductase	-
KMZ68_RS11875 (KMZ68_11875)	2501236..2502759	-	1524	WP_215615942.1	amidophosphoribosyltransferase	-
KMZ68_RS11880 (KMZ68_11880)	2502783..2503412	-	630	WP_215615943.1	CvpA family protein	-
KMZ68_RS11885 (KMZ68_11885)	2503574..2505049	-	1476	WP_215615944.1	DNA repair protein RadA	-
KMZ68_RS11890 (KMZ68_11890)	2505289..2505477	+	189	WP_215615945.1	type II toxin-antitoxin system HicA family toxin	Toxin
KMZ68_RS11895 (KMZ68_11895)	2505483..2505881	+	399	WP_215615946.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KMZ68_RS11900 (KMZ68_11900)	2506096..2506245	-	150	WP_249779596.1	transporter associated domain-containing protein	-
KMZ68_RS11905 (KMZ68_11905)	2506571..2507974	+	1404	WP_215615947.1	hypothetical protein	-
KMZ68_RS11910 (KMZ68_11910)	2508188..2509477	-	1290	WP_215615948.1	hemolysin family protein	-
KMZ68_RS11915 (KMZ68_11915)	2509619..2510866	-	1248	WP_215615949.1	alanine racemase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7135.32 Da
• Isoelectric Point: 11.6831

>T204693 WP_215615945.1 NZ_CP076135:2505289-2505477 [Bradyrhizobium sediminis]
MKSREIISALQRDGWHEVARKGSHVQFKHPRKKGRVTVPHPERDIPVGTLKSIEKQSGLKLR

Nucleotide

• Length: 189 bp

>T204693 NZ_CP101212:c63967-63818 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 13918.69 Da
• Isoelectric Point: 4.2685

>AT204693 WP_215615946.1 NZ_CP076135:2505483-2505881 [Bradyrhizobium sediminis]
MGQYIGLIHKEADSHFGVSFPDFPGVATAGTTLDDARAMAEEALAFHIEGLVEDGEAIPEPSSLEDVMADPDNRSGVAIL
VAAKTEAPKVIRVNVTLPGDILEQIDKYAEAHGLSRSGFLTQAAKKAMLEAA

Nucleotide

• Length: 399 bp

>AT204693 NZ_CP101212:64011-64072 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT