204691

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 3618654..3619387 Replicon chromosome
Accession NZ_CP076134
Organism Bradyrhizobium sediminis strain S2-20-1

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag KMZ29_RS17535 Protein ID WP_249779721.1
Coordinates 3618989..3619387 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag KMZ29_RS17530 Protein ID WP_215620402.1
Coordinates 3618654..3618992 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ29_RS17515 (KMZ29_17515) 3614136..3615902 + 1767 WP_215620400.1 DUF87 domain-containing protein -
KMZ29_RS17520 (KMZ29_17520) 3616471..3616974 + 504 WP_215620401.1 hypothetical protein -
KMZ29_RS17525 (KMZ29_17525) 3617230..3618383 + 1154 WP_215620300.1 IS3 family transposase -
KMZ29_RS17530 (KMZ29_17530) 3618654..3618992 - 339 WP_215620402.1 helix-turn-helix transcriptional regulator Antitoxin
KMZ29_RS17535 (KMZ29_17535) 3618989..3619387 - 399 WP_249779721.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ29_RS17540 (KMZ29_17540) 3619701..3620279 + 579 WP_215620403.1 peroxidase-related enzyme -
KMZ29_RS17545 (KMZ29_17545) 3620310..3620804 + 495 WP_215620404.1 MgtC/SapB family protein -
KMZ29_RS17550 (KMZ29_17550) 3620948..3621295 + 348 WP_215620405.1 hypothetical protein -
KMZ29_RS17555 (KMZ29_17555) 3621484..3621771 + 288 WP_215602438.1 acyl carrier protein -
KMZ29_RS17560 (KMZ29_17560) 3621781..3622251 + 471 WP_215620406.1 3-hydroxyacyl-ACP dehydratase FabZ family protein -
KMZ29_RS17565 (KMZ29_17565) 3622248..3623438 + 1191 WP_215620407.1 beta-ketoacyl-ACP synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-114)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-94)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14965.23 Da        Isoelectric Point: 10.3458

>T204691 WP_249779721.1 NZ_CP076134:c3619387-3618989 [Bradyrhizobium sediminis]
MKEVTIERPEPNPCVFIGSSRKDLKRFPAKVQNRMGHALHQVQEGEEPIAAKALKGFGGRAILELVDDFDSNTYRAVYTV
RFAGMVYVLHAFQKKAKKGIATPQQDIELIKSRLRDAEEHYRARTDKGGRKP

Download         Length: 399 bp

>T204691 NZ_CP101210:c4838798-4838487 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12673.70 Da        Isoelectric Point: 8.5556

>AT204691 WP_215620402.1 NZ_CP076134:c3618992-3618654 [Bradyrhizobium sediminis]
MTKRKIEAYEGSGNVFADLGLPNPEERLLKSSIVTELHRLIKERDLTQVKAAKLIGVSQPDLSHLLRGDFDDYSAERLMK
MLTVFEQDIEIVMRPHRKAGEPGRITFKPVAA

Download         Length: 339 bp

>AT204691 NZ_CP101210:c4838486-4838196 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References