Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3431836..3432428 Replicon chromosome
Accession NZ_CP076134
Organism Bradyrhizobium sediminis strain S2-20-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KMZ29_RS16650 Protein ID WP_215615945.1
Coordinates 3432240..3432428 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KMZ29_RS16645 Protein ID WP_215620250.1
Coordinates 3431836..3432234 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ29_RS26885 3426947..3427069 + 123 WP_256442489.1 hypothetical protein -
KMZ29_RS16630 (KMZ29_16630) 3427319..3428821 + 1503 WP_215620247.1 replicative DNA helicase -
KMZ29_RS16635 (KMZ29_16635) 3428870..3430117 + 1248 WP_215620248.1 alanine racemase -
KMZ29_RS16640 (KMZ29_16640) 3430259..3431548 + 1290 WP_215620249.1 hemolysin family protein -
KMZ29_RS16645 (KMZ29_16645) 3431836..3432234 - 399 WP_215620250.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KMZ29_RS16650 (KMZ29_16650) 3432240..3432428 - 189 WP_215615945.1 type II toxin-antitoxin system HicA family toxin Toxin
KMZ29_RS16655 (KMZ29_16655) 3432670..3434145 + 1476 WP_215615944.1 DNA repair protein RadA -
KMZ29_RS16660 (KMZ29_16660) 3434306..3434935 + 630 WP_215620251.1 CvpA family protein -
KMZ29_RS16665 (KMZ29_16665) 3434968..3436476 + 1509 WP_215624308.1 amidophosphoribosyltransferase -
KMZ29_RS16670 (KMZ29_16670) 3436619..3437359 + 741 WP_215620252.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7135.32 Da        Isoelectric Point: 11.6831

>T204690 WP_215615945.1 NZ_CP076134:c3432428-3432240 [Bradyrhizobium sediminis]
MKSREIISALQRDGWHEVARKGSHVQFKHPRKKGRVTVPHPERDIPVGTLKSIEKQSGLKLR

Download         Length: 189 bp

>T204690 NZ_CP101210:c4563557-4563384 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 13876.61 Da        Isoelectric Point: 4.1863

>AT204690 WP_215620250.1 NZ_CP076134:c3432234-3431836 [Bradyrhizobium sediminis]
MGQYIGLIHKEADSHFGVSFPDFPGVATAGTTLDDARAMAEEALAFHIEGLVEDGEAIPEPSSLEDVMADPDNQSGVAIL
VAAKTEAPKVVRVNVTLPGDILEQIDKYAEAHGLSRSGFLTQAAKKAMLEAA

Download         Length: 399 bp

>AT204690 NZ_CP101210:c4563881-4563585 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAGTTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References