Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 977410..978001 Replicon chromosome
Accession NZ_CP076128
Organism Flammeovirga kamogawensis strain YS10

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KM029_RS03890 Protein ID WP_144075468.1
Coordinates 977705..978001 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KM029_RS03885 Protein ID WP_144075467.1
Coordinates 977410..977697 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM029_RS03875 (KM029_03875) 973174..974652 + 1479 WP_144075465.1 transporter substrate-binding domain-containing protein -
KM029_RS03880 (KM029_03880) 974830..977241 + 2412 WP_144075466.1 alpha-ketoacid dehydrogenase subunit alpha/beta -
KM029_RS03885 (KM029_03885) 977410..977697 - 288 WP_144075467.1 putative addiction module antidote protein Antitoxin
KM029_RS03890 (KM029_03890) 977705..978001 - 297 WP_144075468.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KM029_RS03895 (KM029_03895) 978913..980151 - 1239 WP_144075469.1 ABC transporter permease -
KM029_RS03900 (KM029_03900) 980217..980420 - 204 WP_126612946.1 exodeoxyribonuclease VII small subunit -
KM029_RS03905 (KM029_03905) 980472..981845 - 1374 WP_184679461.1 exodeoxyribonuclease VII large subunit -
KM029_RS03910 (KM029_03910) 981832..982170 - 339 WP_144075472.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-91)

Antitoxin

Uncharacterized protein HI1420

(15-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11578.71 Da        Isoelectric Point: 10.4783

>T204686 WP_144075468.1 NZ_CP076128:c978001-977705 [Flammeovirga kamogawensis]
MYKLEKTDIFDKWLRKLKDRRAKVKILFRLQLIEEKGHFGDCEPIGKGLSELRIHYGKGYRIYLKKKNDKIVILLSGGDK
STQNKDIDKAIDIWKSLK

Download         Length: 297 bp

>T204686 NZ_CP101210:c3867767-3867378 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACGATGCAACTGGCCCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10357.81 Da        Isoelectric Point: 4.8047

>AT204686 WP_144075467.1 NZ_CP076128:c977697-977410 [Flammeovirga kamogawensis]
MKEEVSKLNISEYLDDDDMIAEYLNMVLEEGDSNDIITALGHISKAIGMSKIAKQTGLSRTSLYKALSEGSKPQFETILK
VVRAIGGNLHVNTAS

Download         Length: 288 bp

>AT204686 NZ_CP101210:c3868225-3867857 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATTCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References