Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 897408..897885 Replicon chromosome
Accession NC_002758
Organism Staphylococcus aureus subsp. aureus Mu50

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAV_RS04485 Protein ID WP_000052076.1
Coordinates 897408..897596 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAV_RS04490 Protein ID WP_001059690.1
Coordinates 897625..897885 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAV_RS04455 893402..893923 + 522 WP_000824482.1 hypothetical protein -
SAV_RS04460 894264..894950 + 687 WP_000141557.1 thermonuclease family protein -
SAV_RS04465 895307..895507 + 201 WP_001059082.1 cold-shock protein -
SAV_RS04470 895999..896217 - 219 WP_000005886.1 hypothetical protein -
SAV_RS04475 896279..896563 - 285 WP_001004399.1 hypothetical protein -
SAV_RS04480 896651..897220 - 570 WP_001106654.1 hypothetical protein -
SAV_RS04485 897408..897596 - 189 WP_000052076.1 hypothetical protein Toxin
SAV_RS04490 897625..897885 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAV_RS04495 898226..898429 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAV_RS04500 898426..898662 - 237 WP_000349581.1 hypothetical protein -
SAV_RS04505 898887..899468 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAV_RS04510 899541..900158 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAV_RS04515 900313..900807 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAV_RS04520 901206..901628 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAV_RS04525 901776..902492 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T20467 WP_000052076.1 NC_002758:c897596-897408 [Staphylococcus aureus subsp. aureus Mu50]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T20467 NC_002758:c897596-897408 [Staphylococcus aureus subsp. aureus Mu50]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT20467 WP_001059690.1 NC_002758:c897885-897625 [Staphylococcus aureus subsp. aureus Mu50]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT20467 NC_002758:c897885-897625 [Staphylococcus aureus subsp. aureus Mu50]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References