Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 870984..871513 Replicon chromosome
Accession NC_002758
Organism Staphylococcus aureus subsp. aureus Mu50

Toxin (Protein)


Gene name TscT Uniprot ID K7ZRX2
Locus tag SAV_RS04325 Protein ID WP_001103933.1
Coordinates 871196..871513 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A6B0BJC0
Locus tag SAV_RS04320 Protein ID WP_001058487.1
Coordinates 870984..871193 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAV_RS04290 867435..867899 + 465 WP_001085183.1 SsrA-binding protein SmpB -
SAV_RS04295 868462..869568 - 1107 WP_000121223.1 site-specific integrase -
SAV_RS04300 869574..870221 - 648 WP_072474260.1 helix-turn-helix domain-containing protein -
SAV_RS04305 870379..870585 + 207 WP_001060953.1 hypothetical protein -
SAV_RS04310 870621..870848 + 228 WP_000164237.1 helix-turn-helix domain-containing protein -
SAV_RS04315 870845..870991 + 147 WP_000784893.1 hypothetical protein -
SAV_RS04320 870984..871193 + 210 WP_001058487.1 hypothetical protein Antitoxin
SAV_RS04325 871196..871513 + 318 WP_001103933.1 DUF1474 family protein Toxin
SAV_RS04330 871580..872449 + 870 WP_001002695.1 primase alpha helix C-terminal domain-containing protein -
SAV_RS04335 872466..873935 + 1470 WP_001668899.1 virulence-associated E family protein -
SAV_RS04340 874221..874583 + 363 WP_001039169.1 hypothetical protein -
SAV_RS04345 874585..874869 + 285 WP_000998179.1 hypothetical protein -
SAV_RS04350 874866..875507 + 642 WP_001019810.1 hypothetical protein -
SAV_RS04355 875957..876298 + 342 WP_001190615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12511.13 Da        Isoelectric Point: 4.6364

>T20466 WP_001103933.1 NC_002758:871196-871513 [Staphylococcus aureus subsp. aureus Mu50]
MNWEIKDLMCDIEVIKEKINDVAIKHGWFVEDKFVKNELETKQEHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASSENFGEESDDAKKLKITE

Download         Length: 318 bp

>T20466 NC_002758:871196-871513 [Staphylococcus aureus subsp. aureus Mu50]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAGAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8228.24 Da        Isoelectric Point: 4.1682

>AT20466 WP_001058487.1 NC_002758:870984-871193 [Staphylococcus aureus subsp. aureus Mu50]
MNNEQKEVIEHVVYQLELSIMNNFESYEHTEYVDGIEVVSEISPEKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT20466 NC_002758:870984-871193 [Staphylococcus aureus subsp. aureus Mu50]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTATCATGAATAATTTTGAAAGTTA
TGAACACACGGAATATGTTGATGGTATTGAAGTGGTTTCAGAGATCAGTCCTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAAAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7ZRX2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0BJC0

References