Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1434424..1435080 | Replicon | chromosome |
| Accession | NZ_CP076115 | ||
| Organism | Ralstonia solanacearum strain Rs-SY1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | KME70_RS06820 | Protein ID | WP_082240000.1 |
| Coordinates | 1434895..1435080 (-) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A0S4XBS4 |
| Locus tag | KME70_RS06815 | Protein ID | WP_028853163.1 |
| Coordinates | 1434424..1434825 (-) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KME70_RS06785 (KME70_06785) | 1429698..1430006 | + | 309 | WP_071508341.1 | hypothetical protein | - |
| KME70_RS06790 (KME70_06790) | 1430012..1430281 | + | 270 | WP_118891130.1 | hypothetical protein | - |
| KME70_RS06795 (KME70_06795) | 1430278..1430637 | + | 360 | WP_118891131.1 | hypothetical protein | - |
| KME70_RS06800 (KME70_06800) | 1431179..1431757 | + | 579 | WP_162904219.1 | D-alanyl-D-alanine carboxypeptidase family protein | - |
| KME70_RS06805 (KME70_06805) | 1431770..1432648 | + | 879 | WP_167801032.1 | hypothetical protein | - |
| KME70_RS06810 (KME70_06810) | 1433132..1434172 | - | 1041 | WP_167801031.1 | LysM domain-containing protein | - |
| KME70_RS06815 (KME70_06815) | 1434424..1434825 | - | 402 | WP_028853163.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| KME70_RS06820 (KME70_06820) | 1434895..1435080 | - | 186 | WP_082240000.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| KME70_RS06825 (KME70_06825) | 1435521..1435715 | + | 195 | WP_011001649.1 | hypothetical protein | - |
| KME70_RS06830 (KME70_06830) | 1435787..1437760 | + | 1974 | WP_071623776.1 | bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC | - |
| KME70_RS06835 (KME70_06835) | 1438015..1439364 | + | 1350 | WP_011001651.1 | trigger factor | - |
| KME70_RS06840 (KME70_06840) | 1439394..1440047 | + | 654 | WP_003267806.1 | ATP-dependent Clp endopeptidase proteolytic subunit ClpP | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1393680..1441487 | 47807 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6887.05 Da Isoelectric Point: 10.7125
>T204641 WP_082240000.1 NZ_CP076115:c1435080-1434895 [Ralstonia solanacearum]
MQSAQLIRMLEDDGWQLVRVNGSHHHYKHPEKPGLLTVPHPKKDLPIGTVRSIQKKAAGLK
MQSAQLIRMLEDDGWQLVRVNGSHHHYKHPEKPGLLTVPHPKKDLPIGTVRSIQKKAAGLK
Download Length: 186 bp
>T204641 NZ_CP101197:c838224-837847 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14752.56 Da Isoelectric Point: 4.4190
>AT204641 WP_028853163.1 NZ_CP076115:c1434825-1434424 [Ralstonia solanacearum]
MQFPIAIHKDEGSVYGVTVPDIPGVHSWGDTIDDAVRNTREAIAGHLQTLVELGEDVDVTCSTIEDLTKQDEYAGAVWAL
IDVDAEELDRTPERINVSLPRFVLKKLDRFAENRHETRSGLLARAAMELMAHG
MQFPIAIHKDEGSVYGVTVPDIPGVHSWGDTIDDAVRNTREAIAGHLQTLVELGEDVDVTCSTIEDLTKQDEYAGAVWAL
IDVDAEELDRTPERINVSLPRFVLKKLDRFAENRHETRSGLLARAAMELMAHG
Download Length: 402 bp
>AT204641 NZ_CP101197:c838682-838314 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACAACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACAACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|