Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2229334..2229935 Replicon chromosome
Accession NZ_CP076113
Organism Pasteurella multocida strain GS2020-X2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KMZ33_RS10690 Protein ID WP_241951483.1
Coordinates 2229334..2229648 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KMZ33_RS10695 Protein ID WP_241951484.1
Coordinates 2229645..2229935 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ33_RS10640 2224728..2225513 - 786 WP_241951477.1 phage recombination protein Bet -
KMZ33_RS10645 2225517..2226500 - 984 WP_241951478.1 hypothetical protein -
KMZ33_RS10650 2226503..2226664 - 162 WP_241951479.1 hypothetical protein -
KMZ33_RS10655 2226678..2226905 - 228 WP_111759095.1 hypothetical protein -
KMZ33_RS10660 2226892..2227173 - 282 WP_241951480.1 hypothetical protein -
KMZ33_RS10665 2227218..2227859 - 642 WP_241951481.1 DUF3560 domain-containing protein -
KMZ33_RS10685 2228645..2228872 - 228 WP_241951482.1 hypothetical protein -
KMZ33_RS10690 2229334..2229648 + 315 WP_241951483.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ33_RS10695 2229645..2229935 + 291 WP_241951484.1 putative addiction module antidote protein Antitoxin
KMZ33_RS10700 2229963..2230421 - 459 WP_241951485.1 hypothetical protein -
KMZ33_RS10705 2230405..2231352 - 948 WP_241951486.1 hypothetical protein -
KMZ33_RS10710 2231420..2232109 - 690 WP_241951487.1 helix-turn-helix transcriptional regulator -
KMZ33_RS10715 2232237..2232446 + 210 WP_005720263.1 helix-turn-helix transcriptional regulator -
KMZ33_RS10720 2232495..2232947 + 453 WP_241951488.1 hypothetical protein -
KMZ33_RS10725 2232999..2233682 + 684 WP_078737816.1 phage antirepressor KilAC domain-containing protein -
KMZ33_RS10730 2233679..2234506 + 828 WP_241951489.1 replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2214800..2268751 53951


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(6-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11706.56 Da        Isoelectric Point: 9.2757

>T204639 WP_241951483.1 NZ_CP076113:2229334-2229648 [Pasteurella multocida]
MLDIIETTVFNKWLKELEDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKVLWEEIKQKEGVNV

Download         Length: 315 bp

>T204639 NZ_CP101197:c629980-629516 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAGCCCATTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10586.23 Da        Isoelectric Point: 5.1548

>AT204639 WP_241951484.1 NZ_CP076113:2229645-2229935 [Pasteurella multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEVLETGGTNEFISALGDVARARGMTELAEKTGLGRESLYKTLSYGSKPRFDTI
MKITQALGIKLVPTHI

Download         Length: 291 bp

>AT204639 NZ_CP101197:c630315-629980 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACACTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References