Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 829163..829764 Replicon chromosome
Accession NZ_CP076113
Organism Pasteurella multocida strain GS2020-X2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KMZ33_RS04205 Protein ID WP_241952129.1
Coordinates 829450..829764 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KMZ33_RS04200 Protein ID WP_241952128.1
Coordinates 829163..829453 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ33_RS04160 824424..824747 - 324 WP_241952121.1 replication protein -
KMZ33_RS04165 824744..825496 - 753 WP_241952122.1 Rha family transcriptional regulator -
KMZ33_RS04170 825766..826056 + 291 WP_241952123.1 hypothetical protein -
KMZ33_RS04175 826085..826543 - 459 WP_241952124.1 hypothetical protein -
KMZ33_RS04180 826593..826793 - 201 WP_241952125.1 YdaS family helix-turn-helix protein -
KMZ33_RS04185 826915..827601 + 687 WP_241952126.1 S24 family peptidase -
KMZ33_RS04190 827731..828261 + 531 WP_047918155.1 hypothetical protein -
KMZ33_RS04195 828254..829141 + 888 WP_241952127.1 hypothetical protein -
KMZ33_RS04200 829163..829453 - 291 WP_241952128.1 putative addiction module antidote protein Antitoxin
KMZ33_RS04205 829450..829764 - 315 WP_241952129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KMZ33_RS04210 830073..830240 - 168 WP_005756653.1 DUF1508 domain-containing protein -
KMZ33_RS04215 830253..830462 + 210 WP_005756656.1 hypothetical protein -
KMZ33_RS04220 830703..830930 + 228 WP_241952130.1 hypothetical protein -
KMZ33_RS04225 830946..831203 + 258 WP_241952131.1 hypothetical protein -
KMZ33_RS04230 831181..831453 - 273 WP_071522856.1 CRISPR-associated protein Cas2 -
KMZ33_RS04235 832319..832630 + 312 WP_083002334.1 helix-turn-helix transcriptional regulator -
KMZ33_RS04240 832605..833573 + 969 WP_241952132.1 reverse transcriptase family protein -
KMZ33_RS04245 833645..834472 + 828 WP_241952133.1 damage-inducible protein D -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 792576..838557 45981


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11677.56 Da        Isoelectric Point: 9.7597

>T204638 WP_241952129.1 NZ_CP076113:c829764-829450 [Pasteurella multocida]
MLDIIETTVFNKWLKELKDLSAKAAILARISRAKSGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIKQKEGVNV

Download         Length: 315 bp

>T204638 NZ_CP101197:216952-217059 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10564.25 Da        Isoelectric Point: 5.7134

>AT204638 WP_241952128.1 NZ_CP076113:c829453-829163 [Pasteurella multocida]
MSKKVELKAFDIAEYLDSEEMIAAYLSEVLETGDTNEFISALGDVARARGMTELAAKTGLGRESLYKTLSHGSKPRFDTI
MKITQALGIKLVPMHI

Download         Length: 291 bp

>AT204638 NZ_CP101197:c216903-216840 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References