Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 424888..425529 Replicon chromosome
Accession NZ_CP076113
Organism Pasteurella multocida strain GS2020-X2

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag KMZ33_RS02075 Protein ID WP_277883190.1
Coordinates 425350..425529 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KMZ33_RS02070 Protein ID WP_241951859.1
Coordinates 424888..425304 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ33_RS02020 420084..420770 + 687 WP_241951849.1 replication protein P -
KMZ33_RS02025 420952..421488 + 537 WP_241951850.1 phage N-6-adenine-methyltransferase -
KMZ33_RS02030 421478..421894 + 417 WP_241951851.1 recombination protein NinB -
KMZ33_RS02035 421912..422151 + 240 WP_241951852.1 hypothetical protein -
KMZ33_RS02040 422155..422382 + 228 WP_241951853.1 hypothetical protein -
KMZ33_RS02045 422375..422953 + 579 WP_241951854.1 recombination protein NinG -
KMZ33_RS02050 422950..423453 + 504 WP_241951855.1 antiterminator Q family protein -
KMZ33_RS02055 423590..423838 + 249 WP_241951856.1 hypothetical protein -
KMZ33_RS02060 423825..424367 + 543 WP_241951857.1 lysozyme -
KMZ33_RS02065 424340..424663 + 324 WP_241951858.1 DUF2570 family protein -
KMZ33_RS02070 424888..425304 - 417 WP_241951859.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KMZ33_RS02075 425350..425529 - 180 WP_277883190.1 type II toxin-antitoxin system HicA family toxin Toxin
KMZ33_RS02080 425783..426247 + 465 WP_241951860.1 DUF1441 family protein -
KMZ33_RS02085 426262..428367 + 2106 WP_241951861.1 phage terminase large subunit family protein -
KMZ33_RS02090 428358..428582 + 225 WP_241951862.1 hypothetical protein -
KMZ33_RS02095 428582..430120 + 1539 WP_241951863.1 phage portal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 405121..448616 43495


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-78)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6675.86 Da        Isoelectric Point: 10.8207

>T204637 WP_277883190.1 NZ_CP076113:c425529-425350 [Pasteurella multocida]
MMKQSEFLRWLKAQGVETKEGSNHIKLYLNGKQSALPRHPSKEIAKGTEIAVKKQLGLK

Download         Length: 180 bp

>T204637 NZ_CP101197:216469-216576 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15543.89 Da        Isoelectric Point: 4.9592

>AT204637 WP_241951859.1 NZ_CP076113:c425304-424888 [Pasteurella multocida]
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFHDAVAMAKDALITSMDFYFEDFRKVPLPSKPEQGEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV

Download         Length: 417 bp

>AT204637 NZ_CP101197:c216420-216357 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References