204632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2030450..2030964 Replicon chromosome
Accession NZ_CP076105
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KMZ21_RS09905 Protein ID WP_000581792.1
Coordinates 2030450..2030659 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KMZ21_RS09910 Protein ID WP_000138932.1
Coordinates 2030671..2030964 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ21_RS09885 (KMZ21_09885) 2025958..2027316 - 1359 WP_000611465.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KMZ21_RS09890 (KMZ21_09890) 2027331..2028401 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KMZ21_RS09895 (KMZ21_09895) 2028719..2029921 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KMZ21_RS09900 (KMZ21_09900) 2030185..2030322 - 138 WP_000828354.1 Lmo0850 family protein -
KMZ21_RS09905 (KMZ21_09905) 2030450..2030659 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KMZ21_RS09910 (KMZ21_09910) 2030671..2030964 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KMZ21_RS09915 (KMZ21_09915) 2031130..2032614 + 1485 WP_000571549.1 cardiolipin synthase -
KMZ21_RS09920 (KMZ21_09920) 2032642..2033289 + 648 WP_001187629.1 HD domain-containing protein -
KMZ21_RS09925 (KMZ21_09925) 2034102..2034974 - 873 WP_000725802.1 membrane protein insertase YidC -
KMZ21_RS09930 (KMZ21_09930) 2035060..2035701 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204632 WP_000581792.1 NZ_CP076105:c2030659-2030450 [Staphylococcus aureus subsp. aureus RN4220]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204632 NZ_CP101178:c4598430-4598278 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204632 WP_000138932.1 NZ_CP076105:c2030964-2030671 [Staphylococcus aureus subsp. aureus RN4220]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204632 NZ_CP101178:c4598201-4598067 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References