204631

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2010693..2011222 Replicon chromosome
Accession NZ_CP076105
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KMZ21_RS09815 Protein ID WP_000621175.1
Coordinates 2010693..2011055 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KMZ21_RS09820 Protein ID WP_000948331.1
Coordinates 2011052..2011222 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ21_RS09795 (KMZ21_09795) 2007683..2008453 - 771 WP_001041103.1 RNA polymerase sigma factor SigB -
KMZ21_RS09800 (KMZ21_09800) 2008428..2008907 - 480 WP_001190829.1 anti-sigma B factor RsbW -
KMZ21_RS09805 (KMZ21_09805) 2008909..2009235 - 327 WP_001052491.1 anti-sigma factor antagonist -
KMZ21_RS09810 (KMZ21_09810) 2009354..2010344 - 991 Protein_1889 PP2C family protein-serine/threonine phosphatase -
KMZ21_RS09815 (KMZ21_09815) 2010693..2011055 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KMZ21_RS09820 (KMZ21_09820) 2011052..2011222 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
KMZ21_RS09825 (KMZ21_09825) 2011307..2012455 - 1149 WP_001281145.1 alanine racemase -
KMZ21_RS09830 (KMZ21_09830) 2012521..2012880 - 360 WP_000581200.1 holo-ACP synthase -
KMZ21_RS09835 (KMZ21_09835) 2012884..2013375 - 492 WP_001205910.1 PH domain-containing protein -
KMZ21_RS09840 (KMZ21_09840) 2013362..2014945 - 1584 WP_001294626.1 PH domain-containing protein -
KMZ21_RS09845 (KMZ21_09845) 2014938..2015417 - 480 WP_001287088.1 hypothetical protein -
KMZ21_RS09850 (KMZ21_09850) 2015626..2016186 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T204631 WP_000621175.1 NZ_CP076105:c2011055-2010693 [Staphylococcus aureus subsp. aureus RN4220]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T204631 NZ_CP101178:c4598201-4598067 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT204631 WP_000948331.1 NZ_CP076105:c2011222-2011052 [Staphylococcus aureus subsp. aureus RN4220]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT204631 NZ_CP101178:c4598430-4598278 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References