Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3762997..3763526 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MT_RS17645 Protein ID WP_003417760.1
Coordinates 3763269..3763526 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MT_RS17640 Protein ID WP_003417757.1
Coordinates 3762997..3763272 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS22700 3759795..3761232 - 1438 Protein_3459 FAD-binding oxidoreductase -
MT_RS17625 3761335..3761724 + 390 WP_003417745.1 DUF732 domain-containing protein -
MT_RS17630 3761738..3762031 - 294 WP_003417749.1 DUF3017 domain-containing protein -
MT_RS17635 3762028..3762873 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MT_RS17640 3762997..3763272 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MT_RS17645 3763269..3763526 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MT_RS17650 3763568..3764758 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MT_RS17655 3764875..3765243 + 369 WP_003417765.1 FHA domain-containing protein -
MT_RS17660 3765240..3765791 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MT_RS17665 3765798..3766379 - 582 WP_003417769.1 ATP/GTP-binding protein -
MT_RS17670 3766360..3766728 - 369 WP_003417772.1 DUF742 domain-containing protein -
MT_RS17675 3766706..3767098 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T20463 WP_003417760.1 NC_002755:3763269-3763526 [Mycobacterium tuberculosis CDC1551]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T20463 NC_002755:3763269-3763526 [Mycobacterium tuberculosis CDC1551]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT20463 WP_003417757.1 NC_002755:3762997-3763272 [Mycobacterium tuberculosis CDC1551]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT20463 NC_002755:3762997-3763272 [Mycobacterium tuberculosis CDC1551]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References