Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 812074..812551 Replicon chromosome
Accession NZ_CP076105
Organism Staphylococcus aureus subsp. aureus RN4220

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag KMZ21_RS03875 Protein ID WP_000052078.1
Coordinates 812074..812262 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KMZ21_RS03880 Protein ID WP_001059690.1
Coordinates 812291..812551 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KMZ21_RS03845 (KMZ21_03845) 808115..808585 + 471 WP_000824472.1 hypothetical protein -
KMZ21_RS03850 (KMZ21_03850) 808926..809612 + 687 WP_001548082.1 thermonuclease family protein -
KMZ21_RS03855 (KMZ21_03855) 809969..810169 + 201 WP_001059082.1 cold-shock protein -
KMZ21_RS03860 (KMZ21_03860) 810665..810883 - 219 WP_000005886.1 hypothetical protein -
KMZ21_RS03865 (KMZ21_03865) 810945..811229 - 285 WP_001004395.1 hypothetical protein -
KMZ21_RS03870 (KMZ21_03870) 811317..811886 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KMZ21_RS03875 (KMZ21_03875) 812074..812262 - 189 WP_000052078.1 hypothetical protein Toxin
KMZ21_RS03880 (KMZ21_03880) 812291..812551 - 261 WP_001059690.1 hypothetical protein Antitoxin
KMZ21_RS03885 (KMZ21_03885) 812892..813095 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KMZ21_RS03890 (KMZ21_03890) 813092..813328 - 237 WP_000368687.1 hypothetical protein -
KMZ21_RS03895 (KMZ21_03895) 813553..814134 + 582 WP_001140693.1 histidine phosphatase family protein -
KMZ21_RS03900 (KMZ21_03900) 814207..814824 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
KMZ21_RS03905 (KMZ21_03905) 814979..815473 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KMZ21_RS03910 (KMZ21_03910) 815872..816294 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KMZ21_RS03915 (KMZ21_03915) 816442..817158 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T204627 WP_000052078.1 NZ_CP076105:c812262-812074 [Staphylococcus aureus subsp. aureus RN4220]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T204627 NZ_CP101176:c1233565-1233074 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT204627 WP_001059690.1 NZ_CP076105:c812551-812291 [Staphylococcus aureus subsp. aureus RN4220]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT204627 NZ_CP101176:c1233852-1233562 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References