Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4807252..4807930 Replicon chromosome
Accession NZ_CP076104
Organism Nocardioides sp. LMS-CY

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KM427_RS22780 Protein ID WP_215525413.1
Coordinates 4807499..4807930 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KM427_RS22775 Protein ID WP_215525412.1
Coordinates 4807252..4807497 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM427_RS22760 (KM427_22760) 4803056..4804444 + 1389 WP_215525409.1 polysaccharide biosynthesis tyrosine autokinase -
KM427_RS22765 (KM427_22765) 4804455..4806200 - 1746 WP_215525410.1 DUF4012 domain-containing protein -
KM427_RS22770 (KM427_22770) 4806464..4806904 - 441 WP_215525411.1 hypothetical protein -
KM427_RS22775 (KM427_22775) 4807252..4807497 + 246 WP_215525412.1 ribbon-helix-helix protein, CopG family Antitoxin
KM427_RS22780 (KM427_22780) 4807499..4807930 + 432 WP_215525413.1 PIN domain-containing protein Toxin
KM427_RS22785 (KM427_22785) 4807996..4808292 - 297 WP_183592058.1 DUF1416 domain-containing protein -
KM427_RS22790 (KM427_22790) 4808487..4809335 - 849 WP_215525414.1 sulfurtransferase -
KM427_RS22795 (KM427_22795) 4809384..4809848 - 465 WP_183592060.1 DUF4395 domain-containing protein -
KM427_RS22800 (KM427_22800) 4810075..4810677 - 603 WP_215525415.1 thioredoxin family protein -
KM427_RS22805 (KM427_22805) 4810737..4811165 + 429 WP_215525416.1 VanZ family protein -
KM427_RS22810 (KM427_22810) 4811170..4811448 - 279 WP_183592063.1 MoaD/ThiS family protein -
KM427_RS22815 (KM427_22815) 4811534..4812271 + 738 WP_183592064.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4795702..4810677 14975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15606.79 Da        Isoelectric Point: 6.9906

>T204626 WP_215525413.1 NZ_CP076104:4807499-4807930 [Nocardioides sp. LMS-CY]
VLFLDVNVLVGAQRNDDSPHARDLRNWLERALMGHEPIGISELALSAMVRIVTHPRVFERPSAPAEAVAFAEALLGSSRV
TAVRPAARHWAIFTELVAGHRLRGNEIPDAYYAAIALEQGATVVTADRGFQRYGVRVLDPTTG

Download         Length: 432 bp

>T204626 NZ_CP101174:c4730715-4730563 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8910.03 Da        Isoelectric Point: 4.5859

>AT204626 WP_215525412.1 NZ_CP076104:4807252-4807497 [Nocardioides sp. LMS-CY]
VRTTVSIDDELLAAAKVLAARTHRTIGSILEEALRKLLYDTEQQTETTSALPDFAYSGGLRQGVDLYDKDAMAELLGEAR
R

Download         Length: 246 bp

>AT204626 NZ_CP101174:c4730486-4730352 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References