Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-StbC
Location 3566833..3567458 Replicon chromosome
Accession NZ_CP076104
Organism Nocardioides sp. LMS-CY

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KM427_RS17035 Protein ID WP_215524673.1
Coordinates 3567057..3567458 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KM427_RS17030 Protein ID WP_183593663.1
Coordinates 3566833..3567060 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM427_RS17020 (KM427_17020) 3564467..3565381 - 915 WP_215524671.1 2-hydroxyacid dehydrogenase -
KM427_RS17025 (KM427_17025) 3565392..3566675 - 1284 WP_215524672.1 deoxyguanosinetriphosphate triphosphohydrolase -
KM427_RS17030 (KM427_17030) 3566833..3567060 + 228 WP_183593663.1 hypothetical protein Antitoxin
KM427_RS17035 (KM427_17035) 3567057..3567458 + 402 WP_215524673.1 type II toxin-antitoxin system VapC family toxin Toxin
KM427_RS17040 (KM427_17040) 3567468..3568334 - 867 WP_215524674.1 hypothetical protein -
KM427_RS17045 (KM427_17045) 3568479..3569636 - 1158 WP_183593660.1 tRNA dihydrouridine synthase DusB -
KM427_RS17050 (KM427_17050) 3569748..3570446 - 699 WP_215524675.1 hypothetical protein -
KM427_RS17055 (KM427_17055) 3570473..3571873 - 1401 WP_183593658.1 glycine--tRNA ligase -
KM427_RS17060 (KM427_17060) 3571926..3572246 - 321 WP_183593657.1 antibiotic biosynthesis monooxygenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13976.03 Da        Isoelectric Point: 4.2876

>T204625 WP_215524673.1 NZ_CP076104:3567057-3567458 [Nocardioides sp. LMS-CY]
VIVLDTSAAIEWLLVRDLGAAVAARFSDPDVTVHAPSLIGVEVAAALRGLVLGGHAQPERASLALADLTAADITLHDPTP
LLPRAWELRDNLTPYDAVYLALAEVLDARLVTTDARIATAPGLRAEIDLVTSP

Download         Length: 402 bp

>T204625 NZ_CP101174:c4730486-4730352 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTTGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8356.58 Da        Isoelectric Point: 11.0140

>AT204625 WP_183593663.1 NZ_CP076104:3566833-3567060 [Nocardioides sp. LMS-CY]
MTMIQIRNVPDDVHRRLKARAALEGVSLSDLALAELRRSLDRPTRRELLELVASREPVRSGPSSPELIDSGRNAP

Download         Length: 228 bp

>AT204625 NZ_CP101174:c4730715-4730563 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References