Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2163080..2163735 Replicon chromosome
Accession NZ_CP076104
Organism Nocardioides sp. LMS-CY

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KM427_RS10480 Protein ID WP_183590484.1
Coordinates 2163307..2163735 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KM427_RS10475 Protein ID WP_183590485.1
Coordinates 2163080..2163310 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KM427_RS10440 (KM427_10440) 2158572..2158790 - 219 WP_183590492.1 hypothetical protein -
KM427_RS10445 (KM427_10445) 2158843..2159400 - 558 WP_183590491.1 GNAT family N-acetyltransferase -
KM427_RS10450 (KM427_10450) 2159486..2160409 + 924 WP_215527146.1 1,2-phenylacetyl-CoA epoxidase subunit A -
KM427_RS10455 (KM427_10455) 2160406..2160687 + 282 WP_183590489.1 1,2-phenylacetyl-CoA epoxidase subunit PaaB -
KM427_RS10460 (KM427_10460) 2160684..2161421 + 738 WP_183590488.1 1,2-phenylacetyl-CoA epoxidase subunit PaaC -
KM427_RS10465 (KM427_10465) 2161418..2161957 + 540 WP_215527147.1 1,2-phenylacetyl-CoA epoxidase subunit PaaD -
KM427_RS10470 (KM427_10470) 2161987..2163045 + 1059 WP_215527148.1 1,2-phenylacetyl-CoA epoxidase subunit PaaE -
KM427_RS10475 (KM427_10475) 2163080..2163310 + 231 WP_183590485.1 antitoxin Antitoxin
KM427_RS10480 (KM427_10480) 2163307..2163735 + 429 WP_183590484.1 PIN domain-containing protein Toxin
KM427_RS10485 (KM427_10485) 2163776..2164780 + 1005 WP_183590483.1 aldo/keto reductase family protein -
KM427_RS10490 (KM427_10490) 2164963..2165547 - 585 WP_183590482.1 DUF3043 domain-containing protein -
KM427_RS10495 (KM427_10495) 2165679..2166494 + 816 WP_183590481.1 PspA/IM30 family protein -
KM427_RS10500 (KM427_10500) 2166531..2167448 + 918 WP_183590480.1 zinc metalloprotease HtpX -
KM427_RS10505 (KM427_10505) 2167448..2168035 + 588 WP_183590479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15670.86 Da        Isoelectric Point: 6.7550

>T204622 WP_183590484.1 NZ_CP076104:2163307-2163735 [Nocardioides sp. LMS-CY]
VRALLDVNVLLALLDSDHVSHRRAWDWLDAEIDQGWASCPLTQNGFVRIISQPRYPNPIRSGQAIELLRQATATAHHEFW
PAEVSVLDAERVRADRVHGPKQVTALYLLALAVARGGRLVTFDESVPVSAVPGAGRDHLTLL

Download         Length: 429 bp

>T204622 NZ_CP101172:c4600989-4600855 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8344.34 Da        Isoelectric Point: 4.5742

>AT204622 WP_183590485.1 NZ_CP076104:2163080-2163310 [Nocardioides sp. LMS-CY]
MRTTLDIDDDVLMVAKERARRERRSAGAILSELARQALNDASDQAARADYGFRPLPSRGGLVTNTLIDEIAAELES

Download         Length: 231 bp

>AT204622 NZ_CP101172:c4601221-4601069 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References