Detailed information of TA system TA204621

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD-PIN
• Location: 2080785..2081461
• Replicon: chromosome
• Accession: NZ_CP076104
• Organism: Nocardioides sp. LMS-CY

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KM427_RS10075
• Protein ID: WP_215527106.1
• Coordinates: 2080785..2081174 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KM427_RS10080
• Protein ID: WP_183590553.1
• Coordinates: 2081171..2081461 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM427_RS10050 (KM427_10050)	2076289..2076597	+	309	WP_183590558.1	DUF2469 domain-containing protein	-
KM427_RS10055 (KM427_10055)	2076726..2077115	+	390	WP_215527103.1	YraN family protein	-
KM427_RS10060 (KM427_10060)	2077115..2078701	+	1587	WP_215527104.1	YifB family Mg chelatase-like AAA ATPase	-
KM427_RS10065 (KM427_10065)	2078698..2079807	+	1110	WP_215527105.1	DNA-processing protein DprA	-
KM427_RS10070 (KM427_10070)	2079836..2080777	+	942	WP_252275245.1	tyrosine recombinase XerC	-
KM427_RS10075 (KM427_10075)	2080785..2081174	-	390	WP_215527106.1	type II toxin-antitoxin system VapC family toxin	Toxin
KM427_RS10080 (KM427_10080)	2081171..2081461	-	291	WP_183590553.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KM427_RS10085 (KM427_10085)	2081458..2082075	-	618	WP_215527107.1	peptidoglycan DD-metalloendopeptidase family protein	-
KM427_RS10090 (KM427_10090)	2082479..2083438	+	960	WP_215527108.1	30S ribosomal protein S2	-
KM427_RS10095 (KM427_10095)	2083477..2084286	+	810	WP_183590550.1	translation elongation factor Ts	-
KM427_RS10100 (KM427_10100)	2084405..2085118	+	714	WP_183590549.1	UMP kinase	-
KM427_RS10105 (KM427_10105)	2085200..2085754	+	555	WP_215527580.1	ribosome recycling factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-118)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13888.84 Da
• Isoelectric Point: 4.4691

>T204621 WP_215527106.1 NZ_CP076104:c2081174-2080785 [Nocardioides sp. LMS-CY]
VKIYLDSSAATKLVVEEPESAALLAYLEERAASAEFVSSILFETELRRAARRRGIDEENVTAAVDLVNLAEAPRAVFKVA
AAIGPMALRSLDAIHLATALREDVDVLVTFDRRLQDAGREAGLVVEAPA

Nucleotide

• Length: 390 bp

>T204621 NZ_CP101172:c1294408-1293917 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCCTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10793.47 Da
• Isoelectric Point: 11.5606

>AT204621 WP_183590553.1 NZ_CP076104:c2081461-2081171 [Nocardioides sp. LMS-CY]
MRGTVSRLMERIPHRRLRNDSSEILRRVADGESFEITNNGEVVAILAPPTAAVSWNLRIVKPAVRKGGWSRLKPVRLPPG
SPALSETLDELREERL

Nucleotide

• Length: 291 bp

>AT204621 NZ_CP101172:c1294695-1294405 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA