Detailed information of TA system TA204618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 2475387..2475922
• Replicon: plasmid p352-1
• Accession: NZ_CP076061
• Organism: Cupriavidus sp. EM10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KLP38_RS28255
• Protein ID: WP_215531151.1
• Coordinates: 2475653..2475922 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KLP38_RS28250
• Protein ID: WP_215531150.1
• Coordinates: 2475387..2475656 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KLP38_RS28230 (KLP38_28230)	2470631..2471506	-	876	WP_215531147.1	LysR family transcriptional regulator	-
KLP38_RS28235 (KLP38_28235)	2471600..2472711	+	1112	Protein_2265	NADH:flavin oxidoreductase/NADH oxidase	-
KLP38_RS28240 (KLP38_28240)	2472740..2474194	-	1455	WP_215531148.1	GntP family permease	-
KLP38_RS28245 (KLP38_28245)	2474197..2475240	-	1044	WP_215531149.1	patatin-like phospholipase family protein	-
KLP38_RS28250 (KLP38_28250)	2475387..2475656	+	270	WP_215531150.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KLP38_RS28255 (KLP38_28255)	2475653..2475922	+	270	WP_215531151.1	Txe/YoeB family addiction module toxin	Toxin
KLP38_RS28260 (KLP38_28260)	2476030..2477205	-	1176	WP_215531152.1	L-rhamnonate dehydratase	-
KLP38_RS28265 (KLP38_28265)	2477231..2478256	-	1026	WP_215531153.1	4-hydroxythreonine-4-phosphate dehydrogenase PdxA	-
KLP38_RS28270 (KLP38_28270)	2478259..2479224	-	966	WP_215531154.1	tripartite tricarboxylate transporter substrate binding protein	-
KLP38_RS28275 (KLP38_28275)	2479457..2480377	+	921	WP_215531155.1	dihydrodipicolinate synthase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	plc / acrB / hcp/tssD / vipB/tssC / katA / gmd / motA / cheW / cheB / cheY / cheZ / flhA / flgC / flgG / fliI / ddhA / katA / adeG / katA	1..2510418	2510418

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10480.79 Da
• Isoelectric Point: 9.5441

>T204618 WP_215531151.1 NZ_CP076061:2475653-2475922 [Cupriavidus sp. EM10]
MTRNILFTADAWEQYLFWQGQDRKTLRRINQLVDDARRSPFEGIGKPEPLKGNLAGFWSRRIDDTNRLVYKADDTAVSIV
SCRYHYGDR

Nucleotide

• Length: 270 bp

>T204618 NZ_CP101170:c1280527-1280036 [Xanthomonas campestris pv. campestris]
ATGACGGTATCGGCGCCGGAACCGCTGACAGCGCATCACCGGGTCGAACCGTTCGCATCGGGCGTGGAGAGCCTGGATCA
CTGGCTCAAGCGCCGCGCCCTGAAAAATCAGGCAACCGGTGCGTCACGGACCTTCGTTGCCTGCGAGGATGACCGCGTGG
TGGCCTATTACGCCCTGGCGTCGAGTGCGGTCGCCGTGGACGCGACGCCCGGCCGCTTCCGTCGCAACATGCCGGACCCG
ATCCCCGTGGTGGTGCTTGGGAGGCTTGCTGTTGACCAATCCCTGCATGGCAGAGGTTTTGGCCGCGCCCTGATGCAGGA
TGCTGGCAAGCGCATCTTGCATGCGGCCGACACCATCGGCATTCGCGGGCTGCTCGTGCATGCGCTCTCGGCGGACGCCA
AGGCGTTTTACGAGCGCATCGGCTTCGAACCTTCCCCGCTGGATCCCATGGTGCTGGTCGTCACGCTGGAAGACCTGAAA
GCCAGTCTGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9974.05 Da
• Isoelectric Point: 4.5983

>AT204618 WP_215531150.1 NZ_CP076061:2475387-2475656 [Cupriavidus sp. EM10]
MRTVHFSDARNNLKAVIDQAIEDHDAVLITRRDAPNAVIMSQEQYDSWAETIYLLNSPANAAHLARSLEQLRAGETQSRK
LIDPDDAAE

Nucleotide

• Length: 270 bp

>AT204618 NZ_CP101170:c1280814-1280524 [Xanthomonas campestris pv. campestris]
ATGTCCACACCCAACACTACGCCTGGCAAGCGCGAAACCTTGAATCTCCGCATCAAGCCGGAGGAGCGCAGCCTGATCGA
CCGGGCCGCCAAGGCGCGCGGGAAGAACCGCACCGATTTCATGCTGGACGCAGCGCGCTCGGCGGCCGAGGAAGCCTTGC
TGGACCAGACCCTCATCACGGCCAGCCCGGACGCCTACGCCGCCTTTTTGGCACGGCTGGACATGCCGCCGCAGCCGAAC
GCGCGCCTGCGCAAGACGATGCAGACGCCCGCTCCTTGGGAGAAGGCATGA