Detailed information of TA system TA204616

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1161763..1162378
• Replicon: chromosome
• Accession: NZ_CP076060
• Organism: Cupriavidus sp. EM10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KLP38_RS05625
• Protein ID: WP_215529773.1
• Coordinates: 1162196..1162378 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KLP38_RS05620
• Protein ID: WP_215529772.1
• Coordinates: 1161763..1162167 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KLP38_RS05580 (KLP38_05580)	1157129..1157473	-	345	WP_215529764.1	hypothetical protein	-
KLP38_RS05585 (KLP38_05585)	1157466..1157675	-	210	WP_215529765.1	hypothetical protein	-
KLP38_RS05590 (KLP38_05590)	1157701..1159407	-	1707	WP_215529766.1	hypothetical protein	-
KLP38_RS05595 (KLP38_05595)	1159404..1160066	-	663	WP_215529767.1	hypothetical protein	-
KLP38_RS05600 (KLP38_05600)	1160287..1160529	-	243	WP_215529768.1	KTSC domain-containing protein	-
KLP38_RS32390	1160569..1160703	-	135	WP_255640129.1	hypothetical protein	-
KLP38_RS05605 (KLP38_05605)	1160700..1160903	-	204	WP_215529769.1	hypothetical protein	-
KLP38_RS05610 (KLP38_05610)	1160907..1161170	-	264	WP_215529770.1	hypothetical protein	-
KLP38_RS05615 (KLP38_05615)	1161348..1161557	-	210	WP_215529771.1	hypothetical protein	-
KLP38_RS05620 (KLP38_05620)	1161763..1162167	-	405	WP_215529772.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KLP38_RS05625 (KLP38_05625)	1162196..1162378	-	183	WP_215529773.1	type II toxin-antitoxin system HicA family toxin	Toxin
KLP38_RS31350	1162755..1162880	+	126	Protein_1123	prepilin-type N-terminal cleavage/methylation domain-containing protein	-
KLP38_RS05630 (KLP38_05630)	1162923..1163213	+	291	WP_255640136.1	pilin	-
KLP38_RS05635 (KLP38_05635)	1163226..1164059	-	834	WP_215529775.1	inositol monophosphatase family protein	-
KLP38_RS05640 (KLP38_05640)	1164289..1165176	+	888	WP_215529776.1	RNA methyltransferase	-
KLP38_RS05645 (KLP38_05645)	1165476..1166219	+	744	WP_215529777.1	serine O-acetyltransferase	-
KLP38_RS05650 (KLP38_05650)	1166283..1167073	-	791	Protein_1128	UDP-2,3-diacylglucosamine diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1102368..1162423	60055

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6914.12 Da
• Isoelectric Point: 12.3007

>T204616 WP_215529773.1 NZ_CP076060:c1162378-1162196 [Cupriavidus sp. EM10]
MHSTALIRLLEREGWQLVRSKGSHLTYKHPSRTQIVTVPHPRKDLPTGTVRSIMRTARLV

Nucleotide

• Length: 183 bp

>T204616 NZ_CP101169:416905-417039 [Xanthomonas campestris pv. campestris]
ATGAAGCGTGCAATTGCATTGTTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCCGCGCGCAAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14530.53 Da
• Isoelectric Point: 4.4915

>AT204616 WP_215529772.1 NZ_CP076060:c1162167-1161763 [Cupriavidus sp. EM10]
MEFPIAIHKDPNSVFGVTVADVPGCYSSGDTVEDAIRNAREAIVSHFEVLLTLGEDIALTPTPIAELALRPEFAGAVWAL
ADVDMTQLDTRPERINISLPRFVLHKIDTFVGARHETRSGFLARAALEAMASDA

Nucleotide

• Length: 405 bp

>AT204616 NZ_CP101169:416673-416825 [Xanthomonas campestris pv. campestris]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTCTCGGCCGGCATGATGACTGGCTGTAACACCATGGCTGGTGC
CGGAAAGGACATGCAGGGTGCGGGTGACAAGGTCGAGAAGACCGCCGACAAATGCAGCGACGGTAAGTGCTGA