Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1202401..1203014 Replicon chromosome
Accession NZ_CP076049
Organism Cupriavidus metallidurans strain YL2

Toxin (Protein)


Gene name hicA Uniprot ID Q1LPG3
Locus tag KB891_RS05530 Protein ID WP_011515865.1
Coordinates 1202835..1203014 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A482IMU2
Locus tag KB891_RS05525 Protein ID WP_024569172.1
Coordinates 1202401..1202805 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB891_RS05510 (KB891_05510) 1197791..1198324 + 534 WP_017514429.1 peptidylprolyl isomerase -
KB891_RS05515 (KB891_05515) 1198419..1199471 - 1053 WP_024569170.1 hypothetical protein -
KB891_RS05520 (KB891_05520) 1199468..1202218 - 2751 WP_024569171.1 DNA mismatch repair protein MutS -
KB891_RS05525 (KB891_05525) 1202401..1202805 - 405 WP_024569172.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KB891_RS05530 (KB891_05530) 1202835..1203014 - 180 WP_011515865.1 type II toxin-antitoxin system HicA family toxin Toxin
KB891_RS05535 (KB891_05535) 1203218..1204039 - 822 WP_017513083.1 inositol monophosphatase family protein -
KB891_RS05540 (KB891_05540) 1204291..1205136 + 846 WP_235697763.1 RNA methyltransferase -
KB891_RS05545 (KB891_05545) 1205465..1206208 + 744 WP_017513081.1 serine O-acetyltransferase -
KB891_RS05550 (KB891_05550) 1206257..1207048 - 792 WP_017513080.1 UDP-2,3-diacylglucosamine diphosphatase -
KB891_RS05555 (KB891_05555) 1207117..1207617 - 501 WP_011515870.1 peptidylprolyl isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6790.07 Da        Isoelectric Point: 12.3707

>T204613 WP_011515865.1 NZ_CP076049:c1203014-1202835 [Cupriavidus metallidurans]
MHSSTLIRLLEQKGWKLVRTHGSHFTFKHPRHMLIVTVPHPKKDLPTGTVRNILRTAGL

Download         Length: 180 bp

>T204613 NZ_CP101140:c4791741-4791481 [Streptomyces cavourensis]
GTGAAGTTCGTATGGGATCAGTCGTCCTGGGACGACTACGTCTGGTGGCAGAACCAGGACCGCAAGATCCTCAAGCGGAT
CAACACGCTGCTCCAGGACATCGCCCGGAACGGCAACGAGGGCATGGGCAAGCCGGAGCCCCTGAAGCACGGATTCCAGG
GGTACTGGTCGCGCCGCATCACCGATGAGCACCGGCTCATCTACAAGGTGGTCGACGACGAGGTGCGTGTCGCCGCCTGC
CGCTACCACTACGGGCGCTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14500.64 Da        Isoelectric Point: 5.1814

>AT204613 WP_024569172.1 NZ_CP076049:c1202805-1202401 [Cupriavidus metallidurans]
MDFPIAIHKDANSVYGVTVPDVAGCYSAGESIEEAVRNAREAITTHVVALLSLGEEVVLKATPIGTLMAQPEYAGAIWAL
ADIDMSKLDARPERINISLPRFVLHKIDTFVERRHETRSGFLARVALDAIAGSV

Download         Length: 405 bp

>AT204613 NZ_CP101140:c4791989-4791738 [Streptomyces cavourensis]
ATGCGCACGATGACCTACACCGAGTCGCGGGCGAAGTACGCGGAAACCCTGAGCGCGGTCGTGAACGACCGCGAGGAGGT
CGTGGTCACGCGGGCGGGCCATGAGCCCGTGGTGATAGTGGCGCTCGACGAGTACGAGTCGCTCAAGGAGACCGCGTACC
AGCTCCGCAGCCCGGAGAACGCCCGTCGGCTGCTGGCCTCCATCGAGCGCCTGGAGAGCGGGGGCGGCACGGTGCGGGAG
CTGGCGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0WZI7

Antitoxin

Source ID Structure
AlphaFold DB A0A482IMU2

References