Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3923520..3924505 Replicon chromosome
Accession NZ_CP076048
Organism Rhodococcus sp. USK10

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag I1A62_RS25000 Protein ID WP_219460698.1
Coordinates 3923900..3924505 (+) Length 202 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag I1A62_RS24995 Protein ID WP_219460696.1
Coordinates 3923520..3923903 (+) Length 128 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A62_RS24975 (I1A62_24975) 3919509..3920333 + 825 WP_219460686.1 ABC transporter ATP-binding protein -
I1A62_RS24980 (I1A62_24980) 3920330..3921199 + 870 WP_219460688.1 ABC transporter ATP-binding protein -
I1A62_RS24985 (I1A62_24985) 3921192..3921797 + 606 WP_219460690.1 TetR family transcriptional regulator -
I1A62_RS24990 (I1A62_24990) 3921832..3923340 + 1509 WP_219460693.1 YdiU family protein -
I1A62_RS24995 (I1A62_24995) 3923520..3923903 + 384 WP_219460696.1 ParD-like family protein Antitoxin
I1A62_RS25000 (I1A62_25000) 3923900..3924505 + 606 WP_219460698.1 zeta toxin family protein Toxin
I1A62_RS25005 (I1A62_25005) 3924540..3924992 - 453 WP_219460701.1 helix-turn-helix domain-containing protein -
I1A62_RS25010 (I1A62_25010) 3925083..3925676 + 594 WP_219460704.1 dihydrofolate reductase family protein -
I1A62_RS25015 (I1A62_25015) 3925740..3926123 + 384 WP_219460706.1 PPOX class F420-dependent oxidoreductase -
I1A62_RS25020 (I1A62_25020) 3926143..3926850 - 708 WP_219460709.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
I1A62_RS25025 (I1A62_25025) 3926971..3928188 + 1218 WP_219460712.1 fatty acid desaturase -
I1A62_RS25030 (I1A62_25030) 3928465..3928626 - 162 WP_219460717.1 hypothetical protein -
I1A62_RS25035 (I1A62_25035) 3928623..3929180 - 558 WP_257890918.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-157)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-106)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22073.08 Da        Isoelectric Point: 7.9570

>T204612 WP_219460698.1 NZ_CP076048:3923900-3924505 [Rhodococcus sp. USK10]
VKRLDLVVGCDGAGKSTFVALTLAPLLPASPLVNADEIARQRWPANPAAHSYAAAEIAAKTRSHLLSRGMSFIAETVFSH
PSKLELIDEARTHEYTVVLHVVIIPEELAVRRVRYRVRAGGHDVPEDKIRQRYQRLWGLVAQAFPRCDHVTVYDNSASTG
PRIVAQFTDGYLVGEANWPSWTPTELTASTSPGAQPKDPNV

Download         Length: 606 bp

>T204612 NZ_CP101140:c2514554-2514195 [Streptomyces cavourensis]
ATGCAGTTCAGGGTCATCGTTGTGGAGCCGGCGAGGAGTTGGTTACATGGCTTGCGTCAGCACGACCGGGACACGCTCCT
TCAGGTGACGGCTGCCATCGACGTACTGCAGCGCGAAGGTCCGGCCCTCGGCCGACCGCTCGTCGATCGTGTCGCGGGTG
CGACCCTCGCGAACCTCAAGGAACTGCGGCCCGGTTCGTCGGGCTCCAGCGAGGTGCGGATCCTGTTCGTGTTCGACTCT
GCGCGTAACGCGGTGATCCTCGTCGGCGGCGATAAATCCGGCAGCTGGTCGGGGTGGTATCGGACAGCGATCAAGGTGGC
GGAAGACGCCTATGAGGCATACAGGGACGGGAAGGGATGA

Antitoxin


Download         Length: 128 a.a.        Molecular weight: 13609.06 Da        Isoelectric Point: 4.6530

>AT204612 WP_219460696.1 NZ_CP076048:3923520-3923903 [Rhodococcus sp. USK10]
MPSSGDKVTRLAADLVASAMAEGERQHRTGRQQLEHWARVGRAVSSRQTAARRRVEEALAGRLPIDELGTEEGTVFNAEI
NAAIEEQLATTDYGAALAAQGVTTVALSEDGQIIEYRPDGTHAVLPE

Download         Length: 384 bp

>AT204612 NZ_CP101140:c2514188-2513850 [Streptomyces cavourensis]
GTGAGCGCAGGGCGAAAGGCGGCCGACGCTGTCGGCTGGGACGATCTCAAGGATGAATTCGACCTCTCCGCCGACGAGAC
CCGTGAGGTCGAGCGGCGTGCCGCCCTGCTGCTGTCCGAGGTGAGGGCGCACCGTCTCGCCGAGGTGCGCAAGCGTCAGC
AGATGACGCAGGCGGCAGTGGCCAAGGTTCTCGGCGTCACCCAGGGGCGGGTGTCGGCCATAGAGAAGGGCGAGATCAAC
CGCTCCGAGGTCGAGACGCTGGCCGCGTATGTTGCCGCTCTGGGCGGACAGCTGAAACTCGTGGCCGACTTCGGGGACGA
AACCCTCGTCCTGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References