Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1289153..1289694 Replicon plasmid unnamed2
Accession NZ_CP076047
Organism Rhodococcus sp. USK10

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag I1A62_RS06550 Protein ID WP_219454892.1
Coordinates 1289395..1289694 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag I1A62_RS06545 Protein ID WP_219454891.1
Coordinates 1289153..1289395 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A62_RS06525 (I1A62_06530) 1284928..1285408 - 481 Protein_1237 IS3 family transposase -
I1A62_RS06530 (I1A62_06535) 1285522..1285836 + 315 Protein_1238 transposase -
I1A62_RS06535 (I1A62_06540) 1286491..1287947 + 1457 Protein_1239 group II intron reverse transcriptase/maturase -
I1A62_RS06540 (I1A62_06545) 1288059..1288958 + 900 Protein_1240 IS3 family transposase -
I1A62_RS06545 (I1A62_06550) 1289153..1289395 + 243 WP_219454891.1 YlcI/YnfO family protein Antitoxin
I1A62_RS06550 (I1A62_06555) 1289395..1289694 + 300 WP_219454892.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I1A62_RS06555 (I1A62_06560) 1289950..1292313 + 2364 WP_219454894.1 helicase-associated domain-containing protein -
I1A62_RS06560 (I1A62_06565) 1292936..1293262 + 327 Protein_1244 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..1355759 1355759
- inside IScluster/Tn - - 1285513..1293340 7827


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-94)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10531.27 Da        Isoelectric Point: 9.4104

>T204611 WP_219454892.1 NZ_CP076047:1289395-1289694 [Rhodococcus sp. USK10]
MRPIHAAKLDKTRPVLVLTRELVRPHLSRVTVAPITGTVRGLSTEVPVGPANGLEKDSVVSCDNIVTIPVSALGRGLGFF
FPSQEAALTTAIRAAFDLE

Download         Length: 300 bp

>T204611 NZ_CP101137:505189-505443 [Streptomyces sp. M92]
GTGAGGATCGCTTTCACGTCGCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGATGACCAGACGGAT
CAACAGACTGCTCGCCGACACCGCCCGCGACCCGTTCAAGGGCATCGGCAAGCCGGAGCCGCTGAAGGGCGACCTGTCCG
GCTACTGGTCACGGCGCATCGACGACACGCACCGTCTGGTGTACAAGCCGGGCGACGACGAACTGATCGTCGTCCAGGCG
CGGTACCACTACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8890.92 Da        Isoelectric Point: 4.8553

>AT204611 WP_219454891.1 NZ_CP076047:1289153-1289395 [Rhodococcus sp. USK10]
MSTQIAVRLPDEIVAFVDGEVRDHRAPSRAALVLRALERERRRQVAARDAEILSRARGEDDPDGLDDLARHAAGLFSDLD

Download         Length: 243 bp

>AT204611 NZ_CP101137:504929-505192 [Streptomyces sp. M92]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCATGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTGATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACCGTGCACCTGCTGC
GGTCGCCGAGGAACGCCCGCCGTCTGCTCGACTCGATCGCGGAGGCCGAGGCCGGCGAGGCGCGGCACCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References