Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 4375338..4375921 | Replicon | chromosome |
Accession | NZ_CP076043 | ||
Organism | Escherichia coli strain Stbl4 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | S1EZP4 |
Locus tag | ITN70_RS21165 | Protein ID | WP_000254738.1 |
Coordinates | 4375586..4375921 (+) | Length | 112 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | S1P3W5 |
Locus tag | ITN70_RS21160 | Protein ID | WP_000581937.1 |
Coordinates | 4375338..4375586 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ITN70_RS21150 (4371677) | 4371677..4372978 | + | 1302 | WP_000046812.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
ITN70_RS21155 (4373026) | 4373026..4375260 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
ITN70_RS21160 (4375338) | 4375338..4375586 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
ITN70_RS21165 (4375586) | 4375586..4375921 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
ITN70_RS21170 (4375992) | 4375992..4376783 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
ITN70_RS21175 (4377011) | 4377011..4378648 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
ITN70_RS21180 (4378736) | 4378736..4380034 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T204602 WP_000254738.1 NZ_CP076043:4375586-4375921 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T204602 NZ_CP101125:c5911840-5911658 [Pseudomonas nunensis]
ATGCGAAGTCGGGAAATGATCAGGATGATCGAGGGTGATGGTTGGTATCTGGTAGCCGTGAAAGGCAGCCACCATCAATA
CAAACATTCACATAAGCCAGGGAGGGTGACGATCAAACATCCTGACTCGGATCTACCTAAGGGAACGATCAACAGCATAT
TGAAACAGGCGGGCTTGAAATGA
ATGCGAAGTCGGGAAATGATCAGGATGATCGAGGGTGATGGTTGGTATCTGGTAGCCGTGAAAGGCAGCCACCATCAATA
CAAACATTCACATAAGCCAGGGAGGGTGACGATCAAACATCCTGACTCGGATCTACCTAAGGGAACGATCAACAGCATAT
TGAAACAGGCGGGCTTGAAATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT204602 WP_000581937.1 NZ_CP076043:4375338-4375586 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT204602 NZ_CP101125:c5911598-5911197 [Pseudomonas nunensis]
ATGAAATTCCCGGTCGTTCTGCACAAGGATGCCGACTCAGAGTACGGAGTGATCGTCCCGGACGTACCGGGGTGCTTCTC
TGCGGGCAGCACTGTGGCGCAGGCATTCGAAAACGTGAAGGAGGCGTTGTCCTTGCACTACGAGGGCCTGGTCGCCGATG
GCGATCCATTGCCGCAGGTGCGAGAGATTGATGCTCACCTCGATAATCCTGATTACGCCGGTGGCGTGTGGGGAGTGGTC
GAGTTCGATATCACGCCTTACTTCGGCAAGGCGGTACGTTTCAACGCTACGTTGCCTGAGCAACTGCTTGAGCGAATCGA
CCAGACTGTGAGGCGGGATCAGCGTTACAGCTCAAGGTCTGGTTTTTTAGCGGCTGCAGCTCTGCGCGAACTGTCGGCCT
GA
ATGAAATTCCCGGTCGTTCTGCACAAGGATGCCGACTCAGAGTACGGAGTGATCGTCCCGGACGTACCGGGGTGCTTCTC
TGCGGGCAGCACTGTGGCGCAGGCATTCGAAAACGTGAAGGAGGCGTTGTCCTTGCACTACGAGGGCCTGGTCGCCGATG
GCGATCCATTGCCGCAGGTGCGAGAGATTGATGCTCACCTCGATAATCCTGATTACGCCGGTGGCGTGTGGGGAGTGGTC
GAGTTCGATATCACGCCTTACTTCGGCAAGGCGGTACGTTTCAACGCTACGTTGCCTGAGCAACTGCTTGAGCGAATCGA
CCAGACTGTGAGGCGGGATCAGCGTTACAGCTCAAGGTCTGGTTTTTTAGCGGCTGCAGCTCTGCGCGAACTGTCGGCCT
GA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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