Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3171693..3172241 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag MT_RS15040 Protein ID WP_003414602.1
Coordinates 3171978..3172241 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag MT_RS15035 Protein ID WP_003414599.1
Coordinates 3171693..3171974 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS15010 3167316..3168173 - 858 WP_003899513.1 type I methionyl aminopeptidase -
MT_RS15015 3168215..3168799 - 585 WP_003899514.1 DUF1707 domain-containing protein -
MT_RS15020 3168903..3169151 + 249 WP_003913411.1 antitoxin VapB23 -
MT_RS15025 3169148..3169528 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
MT_RS15030 3169610..3171421 - 1812 WP_003414596.1 penicillin-binding protein -
MT_RS15035 3171693..3171974 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
MT_RS15040 3171978..3172241 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MT_RS15045 3172614..3173468 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
MT_RS15050 3173524..3174687 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
MT_RS15055 3174704..3175918 - 1215 WP_003899518.1 zinc metalloprotease Rip -
MT_RS15060 3175926..3177167 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T20460 WP_003414602.1 NC_002755:3171978-3172241 [Mycobacterium tuberculosis CDC1551]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T20460 NC_002755:3171978-3172241 [Mycobacterium tuberculosis CDC1551]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT20460 WP_003414599.1 NC_002755:3171693-3171974 [Mycobacterium tuberculosis CDC1551]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT20460 NC_002755:3171693-3171974 [Mycobacterium tuberculosis CDC1551]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References