204595

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 2769001..2769815 Replicon chromosome
Accession NZ_CP076043
Organism Escherichia coli strain Stbl4

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag ITN70_RS13530 Protein ID WP_001054376.1
Coordinates 2769001..2769258 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag ITN70_RS13535 Protein ID WP_001309181.1
Coordinates 2769270..2769815 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ITN70_RS13510 (2764289) 2764289..2765395 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
ITN70_RS13515 (2765460) 2765460..2766440 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
ITN70_RS21815 (2766550) 2766550..2766755 + 206 Protein_2648 HNH endonuclease -
ITN70_RS13520 (2767023) 2767023..2768263 - 1241 Protein_2649 helicase YjhR -
ITN70_RS21820 (2768379) 2768379..2768510 + 132 WP_001309182.1 hypothetical protein -
ITN70_RS13530 (2769001) 2769001..2769258 + 258 WP_001054376.1 YjhX family toxin Toxin
ITN70_RS13535 (2769270) 2769270..2769815 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
ITN70_RS13540 (2769871) 2769871..2770617 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
ITN70_RS13545 (2770786) 2770786..2771004 + 219 Protein_2654 hypothetical protein -
ITN70_RS13550 (2771042) 2771042..2771158 + 117 Protein_2655 VOC family protein -
ITN70_RS13555 (2771403) 2771403..2772524 + 1122 WP_000010829.1 M42 family metallopeptidase -
ITN70_RS13560 (2772521) 2772521..2772799 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
ITN70_RS13565 (2772811) 2772811..2774124 + 1314 WP_000460842.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T204595 WP_001054376.1 NZ_CP076043:2769001-2769258 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T204595 NZ_CP101124:c2031169-2030960 [Staphylococcus aureus subsp. aureus RN4220]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT204595 WP_001309181.1 NZ_CP076043:2769270-2769815 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT204595 NZ_CP101124:c2031474-2031181 [Staphylococcus aureus subsp. aureus RN4220]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References