Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN_Sll0205-like-Phd
Location 3130834..3131438 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name vapC Uniprot ID P71623
Locus tag MT_RS14840 Protein ID WP_003414492.1
Coordinates 3130834..3131226 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A829CBY8
Locus tag MT_RS14845 Protein ID WP_003414495.1
Coordinates 3131223..3131438 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS14810 3125984..3126772 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
MT_RS14815 3127106..3127651 - 546 WP_003913758.1 DUF1802 family protein -
MT_RS14820 3127923..3128807 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
MT_RS14825 3128810..3129697 - 888 WP_042507815.1 type IV toxin-antitoxin system AbiEi family antitoxin -
MT_RS14830 3130002..3130547 - 546 WP_003899500.1 DUF1802 family protein -
MT_RS14835 3130544..3130813 - 270 WP_003414489.1 DUF2277 family protein -
MT_RS14840 3130834..3131226 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin Toxin
MT_RS14845 3131223..3131438 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MT_RS14850 3131485..3132234 + 750 WP_003414497.1 enoyl-CoA hydratase -
MT_RS14855 3132313..3133395 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -
MT_RS14860 3133388..3134696 - 1309 Protein_2915 ABC transporter substrate-binding protein -
MT_RS14865 3134699..3135526 - 828 WP_003414504.1 carbohydrate ABC transporter permease -
MT_RS14870 3135523..3136434 - 912 WP_003414505.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-130)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14610.74 Da        Isoelectric Point: 6.7594

>T20459 WP_003414492.1 NC_002755:c3131226-3130834 [Mycobacterium tuberculosis CDC1551]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Download         Length: 393 bp

>T20459 NC_002755:c3131226-3130834 [Mycobacterium tuberculosis CDC1551]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7511.55 Da        Isoelectric Point: 4.9732

>AT20459 WP_003414495.1 NC_002755:c3131438-3131223 [Mycobacterium tuberculosis CDC1551]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Download         Length: 216 bp

>AT20459 NC_002755:c3131438-3131223 [Mycobacterium tuberculosis CDC1551]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BWM8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CBY8

References