Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1595003..1595517 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KI244_RS07935 Protein ID WP_000581792.1
Coordinates 1595003..1595212 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI244_RS07940 Protein ID WP_000138932.1
Coordinates 1595224..1595517 (-) Length 98 a.a.

Genomic Context

KI244_RS07925KI244_RS07945KI244_RS07950KI244_RS07915KI244_RS07920KI244_RS07930KI244_RS07935KI244_RS07940KI244_RS07955KI244_RS07960
Location: 1593272..1594474 (1203 bp)
Type: Others
Protein ID: WP_001109939.1
Location: 1595683..1597167 (1485 bp)
Type: Others
Protein ID: WP_000571549.1
Location: 1597195..1597842 (648 bp)
Type: Others
Protein ID: WP_001187630.1
Location: 1590511..1591869 (1359 bp)
Type: Others
Protein ID: WP_045177762.1
Location: 1591884..1592954 (1071 bp)
Type: Others
Protein ID: WP_000159631.1
Location: 1594738..1594875 (138 bp)
Type: Others
Protein ID: WP_000828354.1
Location: 1595003..1595212 (210 bp)
Type: Toxin
Protein ID: WP_000581792.1
Location: 1595224..1595517 (294 bp)
Type: Antitoxin
Protein ID: WP_000138932.1
Location: 1598308..1599180 (873 bp)
Type: Others
Protein ID: WP_000725802.1
Location: 1599266..1599907 (642 bp)
Type: Others
Protein ID: WP_000483164.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KI244_RS07915 (KI244_07915)1590511..1591869-1359WP_045177762.1UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase-
KI244_RS07920 (KI244_07920)1591884..1592954-1071WP_000159631.1D-alanine--D-alanine ligase-
KI244_RS07925 (KI244_07925)1593272..1594474+1203WP_001109939.1FtsW/RodA/SpoVE family cell cycle protein-
KI244_RS07930 (KI244_07930)1594738..1594875-138WP_000828354.1Lmo0850 family protein-
KI244_RS07935 (KI244_07935)1595003..1595212-210WP_000581792.1heavy metal-associated domain-containing proteinToxin
KI244_RS07940 (KI244_07940)1595224..1595517-294WP_000138932.1copper-sensing transcriptional repressor CsoRAntitoxin
KI244_RS07945 (KI244_07945)1595683..1597167+1485WP_000571549.1cardiolipin synthase-
KI244_RS07950 (KI244_07950)1597195..1597842+648WP_001187630.1HD domain-containing protein-
KI244_RS07955 (KI244_07955)1598308..1599180-873WP_000725802.1membrane protein insertase YidC-
KI244_RS07960 (KI244_07960)1599266..1599907-642WP_000483164.1thiamine phosphate synthase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204573 WP_000581792.1 NZ_CP076029:c1595212-1595003 [Staphylococcus sp. MZ9]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204573 NZ_CP101114:779357-779683 [Bartonella harrusi]
ATGAAGCGTGGATCTCTCGTAACAATAGCGATGCAGGGTGATTTTGGTAAACCAAGACCTGCATTAATAATTCAAGCCAA
TCAATTCAGTGAACATACAAGCGTAACAGTTTTACCAATTACAAGTACACTTATTGCAGCGCCATTACTTCGCATTACTA
TTCAACCAGATGCCAAAAATGGTTTACAAAAGCTTTCACAAGTGATGATTGATAAGATCATGACGGTAAGATGCGAAAAG
GTTAGCCCAGCTTTCGGTTCTATTCATGCAGATAAAATGGTAGAAATTGAACGCTGTTTGGCTGTGTTTTTGGGAATAGT
AAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204573 WP_000138932.1 NZ_CP076029:c1595517-1595224 [Staphylococcus sp. MZ9]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204573 NZ_CP101114:779136-779360 [Bartonella harrusi]
ATGGCTACAATGCACGTCAATGAACGCGTTCAAAAACATCGTAACGCACAAAGGAAAGCAGGATTGCGCTTGATGCAAAT
TTGGGTACCAGATACACGCCAACCAAACTTTGCAGAAGAGTGCCGCCGGCAGTGTCGCTTGGTAGCAAAAATGGATAAAA
CAGATACATCTATGCAATTATTTATGGATCAATCTTTAGTGGAAGTTGATGGCTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6FF1

Antitoxin

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Source
ID
Structure
AlphaFold DBW8UW13

References