Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1595003..1595517 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KI244_RS07935 Protein ID WP_000581792.1
Coordinates 1595003..1595212 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI244_RS07940 Protein ID WP_000138932.1
Coordinates 1595224..1595517 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI244_RS07915 (KI244_07915) 1590511..1591869 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KI244_RS07920 (KI244_07920) 1591884..1592954 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KI244_RS07925 (KI244_07925) 1593272..1594474 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KI244_RS07930 (KI244_07930) 1594738..1594875 - 138 WP_000828354.1 Lmo0850 family protein -
KI244_RS07935 (KI244_07935) 1595003..1595212 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KI244_RS07940 (KI244_07940) 1595224..1595517 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KI244_RS07945 (KI244_07945) 1595683..1597167 + 1485 WP_000571549.1 cardiolipin synthase -
KI244_RS07950 (KI244_07950) 1597195..1597842 + 648 WP_001187630.1 HD domain-containing protein -
KI244_RS07955 (KI244_07955) 1598308..1599180 - 873 WP_000725802.1 membrane protein insertase YidC -
KI244_RS07960 (KI244_07960) 1599266..1599907 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204573 WP_000581792.1 NZ_CP076029:c1595212-1595003 [Staphylococcus sp. MZ9]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204573 NZ_CP101114:779357-779683 [Bartonella harrusi]
ATGAAGCGTGGATCTCTCGTAACAATAGCGATGCAGGGTGATTTTGGTAAACCAAGACCTGCATTAATAATTCAAGCCAA
TCAATTCAGTGAACATACAAGCGTAACAGTTTTACCAATTACAAGTACACTTATTGCAGCGCCATTACTTCGCATTACTA
TTCAACCAGATGCCAAAAATGGTTTACAAAAGCTTTCACAAGTGATGATTGATAAGATCATGACGGTAAGATGCGAAAAG
GTTAGCCCAGCTTTCGGTTCTATTCATGCAGATAAAATGGTAGAAATTGAACGCTGTTTGGCTGTGTTTTTGGGAATAGT
AAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204573 WP_000138932.1 NZ_CP076029:c1595517-1595224 [Staphylococcus sp. MZ9]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204573 NZ_CP101114:779136-779360 [Bartonella harrusi]
ATGGCTACAATGCACGTCAATGAACGCGTTCAAAAACATCGTAACGCACAAAGGAAAGCAGGATTGCGCTTGATGCAAAT
TTGGGTACCAGATACACGCCAACCAAACTTTGCAGAAGAGTGCCGCCGGCAGTGTCGCTTGGTAGCAAAAATGGATAAAA
CAGATACATCTATGCAATTATTTATGGATCAATCTTTAGTGGAAGTTGATGGCTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References