Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1575245..1575774 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KI244_RS07845 Protein ID WP_000621175.1
Coordinates 1575245..1575607 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag KI244_RS07850 Protein ID WP_000948331.1
Coordinates 1575604..1575774 (-) Length 57 a.a.

Genomic Context

KI244_RS07825KI244_RS07830KI244_RS07835KI244_RS07840KI244_RS07845KI244_RS07850KI244_RS07855KI244_RS07860KI244_RS07865KI244_RS07870KI244_RS07875KI244_RS07880
Location: 1572223..1572993 (771 bp)
Type: Others
Protein ID: WP_001041102.1
Location: 1572968..1573447 (480 bp)
Type: Others
Protein ID: WP_001190829.1
Location: 1573449..1573775 (327 bp)
Type: Others
Protein ID: WP_001052491.1
Location: 1573894..1574895 (1002 bp)
Type: Others
Protein ID: WP_000390829.1
Location: 1575245..1575607 (363 bp)
Type: Toxin
Protein ID: WP_000621175.1
Location: 1575604..1575774 (171 bp)
Type: Antitoxin
Protein ID: WP_000948331.1
Location: 1575859..1577007 (1149 bp)
Type: Others
Protein ID: WP_001281154.1
Location: 1577073..1577432 (360 bp)
Type: Others
Protein ID: WP_000581197.1
Location: 1577436..1577927 (492 bp)
Type: Others
Protein ID: WP_072353916.1
Location: 1577914..1579497 (1584 bp)
Type: Others
Protein ID: WP_045177766.1
Location: 1579490..1579969 (480 bp)
Type: Others
Protein ID: WP_001287079.1
Location: 1580178..1580738 (561 bp)
Type: Others
Protein ID: WP_001092409.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KI244_RS07825 (KI244_07825)1572223..1572993-771WP_001041102.1RNA polymerase sigma factor SigB-
KI244_RS07830 (KI244_07830)1572968..1573447-480WP_001190829.1anti-sigma B factor RsbW-
KI244_RS07835 (KI244_07835)1573449..1573775-327WP_001052491.1anti-sigma factor antagonist-
KI244_RS07840 (KI244_07840)1573894..1574895-1002WP_000390829.1PP2C family protein-serine/threonine phosphatase-
KI244_RS07845 (KI244_07845)1575245..1575607-363WP_000621175.1type II toxin-antitoxin system PemK/MazF family toxinToxin
KI244_RS07850 (KI244_07850)1575604..1575774-171WP_000948331.1type II toxin-antitoxin system antitoxin MazEAntitoxin
KI244_RS07855 (KI244_07855)1575859..1577007-1149WP_001281154.1alanine racemase-
KI244_RS07860 (KI244_07860)1577073..1577432-360WP_000581197.1holo-ACP synthase-
KI244_RS07865 (KI244_07865)1577436..1577927-492WP_072353916.1PH domain-containing protein-
KI244_RS07870 (KI244_07870)1577914..1579497-1584WP_045177766.1PH domain-containing protein-
KI244_RS07875 (KI244_07875)1579490..1579969-480WP_001287079.1hypothetical protein-
KI244_RS07880 (KI244_07880)1580178..1580738-561WP_001092409.1K(+)-transporting ATPase subunit C-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T204572 WP_000621175.1 NZ_CP076029:c1575607-1575245 [Staphylococcus sp. MZ9]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T204572 NZ_CP101114:c597327-597001 [Bartonella harrusi]
ATGAAGCGTGGATCTCTCGTAACAATAGCGATGCAGGGTGATTTTGGTAAACCAAGACCTGCATTAATAATTCAAGCCAA
TCAATTCAGTGAACATACAAGCGTAACAGTTTTACCAATTACAAGTACACTTATTGCAGCGCCATTACTTCGCATTACTA
TTCAACCAGATGCCAAAAATGGTTTACAAAAGCTTTCACAAGTGATGATTGATAAGATCATGACGGTAAGATGCGAAAAG
GTTAGCCCAGCTTTCGGTTCTATTCATGCAGATAAAATGGTAGAAATTGAACGCTGTTTGGCTGTGTTTTTGGGAATAGT
AAAATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT204572 WP_000948331.1 NZ_CP076029:c1575774-1575604 [Staphylococcus sp. MZ9]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT204572 NZ_CP101114:c597548-597324 [Bartonella harrusi]
ATGGCTACAATGCACGTCAATGAACGCGTTCAAAAACATCGTAACGCACAAAGGAAAGCAGGATTGCGCTTGATGCAAAT
TTGGGTACCAGATACACGCCAACCAAACTTTGCAGAAGAGTGCCGCCGGCAGTGTCGCTTGGTAGCAAAAATGGATAAAA
CAGATACATCTATGCAATTATTTATGGATCAATCTTTAGTGGAAGTTGATGGCTGGACAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VRZ1

References