Detailed information of TA system TA204571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1421521..1422297
• Replicon: chromosome
• Accession: NZ_CP076029
• Organism: Staphylococcus sp. MZ9

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KI244_RS06950
• Protein ID: WP_000031108.1
• Coordinates: 1421521..1421673 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KI244_RS06955
• Protein ID: WP_001251224.1
• Coordinates: 1421698..1422297 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI244_RS06935 (KI244_06935)	1417658..1418479	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KI244_RS06940 (KI244_06940)	1418942..1420327	-	1386	WP_000116229.1	class II fumarate hydratase	-
KI244_RS06945 (KI244_06945)	1420523..1420918	-	396	WP_000901023.1	hypothetical protein	-
KI244_RS06950 (KI244_06950)	1421521..1421673	-	153	WP_000031108.1	SAS053 family protein	Toxin
KI244_RS06955 (KI244_06955)	1421698..1422297	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KI244_RS06960 (KI244_06960)	1422456..1422926	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KI244_RS06965 (KI244_06965)	1422931..1424058	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KI244_RS06970 (KI244_06970)	1424209..1424931	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KI244_RS06975 (KI244_06975)	1424924..1426381	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T204571 WP_000031108.1 NZ_CP076029:c1421673-1421521 [Staphylococcus sp. MZ9]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T204571 NZ_CP101114:322124-322405 [Bartonella harrusi]
ATGCGGACGATTGAACGTACCACTGTCTTTAAACGTGATTTTAAGCGTGAAATGAGAGGGCGATATCGGCATCTTTTAGA
GACTGATTTGCGCCAAATCATTGCAGCGTTAGCAAATGATCAACCTTTAGAACTTCGACATCATGATCATGCATTAACTG
GAAATTGGAAAGATTATCGAGATTGCCATATTCGACCTGATTTGGTTTTGATTTATCGATTAATTGGTCAAGATAGGCTT
ATTTTGGTGCGTCTTGGTTCTCATTCACAGCTTAATCTGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT204571 WP_001251224.1 NZ_CP076029:c1422297-1421698 [Staphylococcus sp. MZ9]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT204571 NZ_CP101114:321874-322137 [Bartonella harrusi]
ATGGCTACCAGTCGCATGGTGCAAGCGCGTGTACCAGAAGAGATCCAAAATGTCGCTAATCAAGTTATTCAAGCCTCTGG
CTTATCGGTGAGTGATGTTGTGAGAGTGTTGATGACGCGTATTGCCCAAGATAAAGCTATTCCGTCCTTCTTATTTCAAC
CCAATGCAGCGACCATAGCGGCTTTTACTGAATTAGATGAAGGCAACTTAAAAAAGTTTAATTCTGTAGACGAATTATTT
GATGATTTATATGCGGACGATTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4