Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3104886..3105456 Replicon chromosome
Accession NC_002755
Organism Mycobacterium tuberculosis CDC1551

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag MT_RS14690 Protein ID WP_003414166.1
Coordinates 3104886..3105242 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag MT_RS14695 Protein ID WP_003901465.1
Coordinates 3105226..3105456 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT_RS14670 3100338..3102026 - 1689 WP_010924579.1 alpha/beta hydrolase family protein -
MT_RS14675 3102030..3102356 - 327 WP_003917682.1 hypothetical protein -
MT_RS14680 3102529..3103116 + 588 WP_003914429.1 DUF3558 family protein -
MT_RS14685 3103135..3104784 + 1650 WP_003899485.1 CocE/NonD family hydrolase -
MT_RS14690 3104886..3105242 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
MT_RS14695 3105226..3105456 - 231 WP_003901465.1 antitoxin MazE Antitoxin
MT_RS14700 3105499..3106542 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
MT_RS22125 3106733..3107008 + 276 WP_003911993.1 DUF1778 domain-containing protein -
MT_RS22310 3107184..3107438 - 255 WP_003917684.1 hypothetical protein -
MT_RS14715 3107586..3107990 + 405 WP_009938577.1 hypothetical protein -
MT_RS14720 3107987..3108178 + 192 WP_003414184.1 hypothetical protein -
MT_RS14725 3108242..3109531 + 1290 Protein_2889 transposase family protein -
MT_RS14730 3109765..3110022 + 258 WP_003899489.1 hypothetical protein -
MT_RS14735 3110127..3110438 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T20457 WP_003414166.1 NC_002755:c3105242-3104886 [Mycobacterium tuberculosis CDC1551]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T20457 NC_002755:c3105242-3104886 [Mycobacterium tuberculosis CDC1551]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT20457 WP_003901465.1 NC_002755:c3105456-3105226 [Mycobacterium tuberculosis CDC1551]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT20457 NC_002755:c3105456-3105226 [Mycobacterium tuberculosis CDC1551]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References