Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsaAT/-
Location 315795..316272 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KI244_RS01525 Protein ID WP_000052076.1
Coordinates 315795..315983 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KI244_RS01530 Protein ID WP_001059690.1
Coordinates 316012..316272 (-) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI244_RS01495 (KI244_01495) 311837..312307 + 471 WP_000824472.1 hypothetical protein -
KI244_RS01500 (KI244_01500) 312648..313333 + 686 Protein_283 thermonuclease family protein -
KI244_RS01505 (KI244_01505) 313690..313890 + 201 WP_001059082.1 cold-shock protein -
KI244_RS01510 (KI244_01510) 314386..314604 - 219 WP_000005886.1 hypothetical protein -
KI244_RS01515 (KI244_01515) 314666..314950 - 285 WP_001004401.1 hypothetical protein -
KI244_RS01520 (KI244_01520) 315038..315607 - 570 WP_045178121.1 lipoprotein N-acylation protein LnsA -
KI244_RS01525 (KI244_01525) 315795..315983 - 189 WP_000052076.1 hypothetical protein Toxin
KI244_RS01530 (KI244_01530) 316012..316272 - 261 WP_001059690.1 hypothetical protein Antitoxin
KI244_RS01535 (KI244_01535) 316613..316816 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KI244_RS01540 (KI244_01540) 316813..317049 - 237 WP_000368687.1 hypothetical protein -
KI244_RS01545 (KI244_01545) 317274..317855 + 582 WP_214958375.1 histidine phosphatase family protein -
KI244_RS01550 (KI244_01550) 317928..318545 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
KI244_RS01555 (KI244_01555) 318700..319194 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KI244_RS01560 (KI244_01560) 319593..320015 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KI244_RS01565 (KI244_01565) 320163..320879 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-104)

Antitoxin

(18-89)


Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T204567 WP_000052076.1 NZ_CP076029:c315983-315795 [Staphylococcus sp. MZ9]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T204567 NZ_CP100765:4190831-4191175 [Serratia nematodiphila]
ATGTGGCAAGTGGTGACCGTCGAACGGTTTGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGCCCGCAATTGGCGCGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GACAGTTGAAGGAGCTGCGCATTCAACATCGCGGGTGCCCTTTCAGGGTGTTTTTCGCCTTTGATCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT204567 WP_001059690.1 NZ_CP076029:c316272-316012 [Staphylococcus sp. MZ9]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT204567 NZ_CP100765:4191181-4191483 [Serratia nematodiphila]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
GATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGTTGGCGGTTTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAGCTGTCATCGCTCAAACGCTATATTGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References