Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 315795..316272 Replicon chromosome
Accession NZ_CP076029
Organism Staphylococcus sp. MZ9

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag KI244_RS01525 Protein ID WP_000052076.1
Coordinates 315795..315983 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KI244_RS01530 Protein ID WP_001059690.1
Coordinates 316012..316272 (-) Length 87 a.a.

Genomic Context

KI244_RS01495KI244_RS01500KI244_RS01505KI244_RS01535KI244_RS01545KI244_RS01565KI244_RS01510KI244_RS01515KI244_RS01520KI244_RS01525KI244_RS01530KI244_RS01540KI244_RS01550KI244_RS01555KI244_RS01560
Location: 311837..312307 (471 bp)
Type: Others
Protein ID: WP_000824472.1
Location: 312648..313333 (686 bp)
Type: Others
Protein ID: Protein_283
Location: 313690..313890 (201 bp)
Type: Others
Protein ID: WP_001059082.1
Location: 316613..316816 (204 bp)
Type: Others
Protein ID: WP_000145163.1
Location: 317274..317855 (582 bp)
Type: Others
Protein ID: WP_214958375.1
Location: 320163..320879 (717 bp)
Type: Others
Protein ID: WP_000150017.1
Location: 314386..314604 (219 bp)
Type: Others
Protein ID: WP_000005886.1
Location: 314666..314950 (285 bp)
Type: Others
Protein ID: WP_001004401.1
Location: 315038..315607 (570 bp)
Type: Others
Protein ID: WP_045178121.1
Location: 315795..315983 (189 bp)
Type: Toxin
Protein ID: WP_000052076.1
Location: 316012..316272 (261 bp)
Type: Antitoxin
Protein ID: WP_001059690.1
Location: 316813..317049 (237 bp)
Type: Others
Protein ID: WP_000368687.1
Location: 317928..318545 (618 bp)
Type: Others
Protein ID: WP_000255553.1
Location: 318700..319194 (495 bp)
Type: Others
Protein ID: WP_000569884.1
Location: 319593..320015 (423 bp)
Type: Others
Protein ID: WP_000974460.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KI244_RS01495 (KI244_01495)311837..312307+471WP_000824472.1hypothetical protein-
KI244_RS01500 (KI244_01500)312648..313333+686Protein_283thermonuclease family protein-
KI244_RS01505 (KI244_01505)313690..313890+201WP_001059082.1cold-shock protein-
KI244_RS01510 (KI244_01510)314386..314604-219WP_000005886.1hypothetical protein-
KI244_RS01515 (KI244_01515)314666..314950-285WP_001004401.1hypothetical protein-
KI244_RS01520 (KI244_01520)315038..315607-570WP_045178121.1lipoprotein N-acylation protein LnsA-
KI244_RS01525 (KI244_01525)315795..315983-189WP_000052076.1hypothetical proteinToxin
KI244_RS01530 (KI244_01530)316012..316272-261WP_001059690.1hypothetical proteinAntitoxin
KI244_RS01535 (KI244_01535)316613..316816+204WP_000145163.1sterile alpha motif-like domain-containing protein-
KI244_RS01540 (KI244_01540)316813..317049-237WP_000368687.1hypothetical protein-
KI244_RS01545 (KI244_01545)317274..317855+582WP_214958375.1histidine phosphatase family protein-
KI244_RS01550 (KI244_01550)317928..318545-618WP_000255553.1LysE/ArgO family amino acid transporter-
KI244_RS01555 (KI244_01555)318700..319194-495WP_000569884.1GNAT family N-acetyltransferase-
KI244_RS01560 (KI244_01560)319593..320015-423WP_000974460.1organic hydroperoxide resistance protein-
KI244_RS01565 (KI244_01565)320163..320879+717WP_000150017.1type I 3-dehydroquinate dehydratase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T204567 WP_000052076.1 NZ_CP076029:c315983-315795 [Staphylococcus sp. MZ9]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T204567 NZ_CP100765:4190831-4191175 [Serratia nematodiphila]
ATGTGGCAAGTGGTGACCGTCGAACGGTTTGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTACAAATTGCAGACGTTCGGCCCGCAATTGGCGCGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GACAGTTGAAGGAGCTGCGCATTCAACATCGCGGGTGCCCTTTCAGGGTGTTTTTCGCCTTTGATCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACAAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT204567 WP_001059690.1 NZ_CP076029:c316272-316012 [Staphylococcus sp. MZ9]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT204567 NZ_CP100765:4191181-4191483 [Serratia nematodiphila]
ATGGCCAAACCTTTATCCCAACTGATCGATAAACTCGATCCCGCCGTCGTTGCCGCCGCCAGGCAAAAAGCGGACCAGGA
GATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGTTGGCGGTTTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAGCTGTCATCGCTCAAACGCTATATTGAGGCGATG
GGCGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0VP18

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VN56

References