Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2163368..2163882 Replicon chromosome
Accession NZ_CP076028
Organism Staphylococcus sp. MZ8

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KI239_RS10605 Protein ID WP_000581792.1
Coordinates 2163368..2163577 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI239_RS10610 Protein ID WP_000138932.1
Coordinates 2163589..2163882 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI239_RS10585 (KI239_10585) 2158876..2160234 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KI239_RS10590 (KI239_10590) 2160249..2161319 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KI239_RS10595 (KI239_10595) 2161637..2162839 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KI239_RS10600 (KI239_10600) 2163103..2163240 - 138 WP_000828354.1 Lmo0850 family protein -
KI239_RS10605 (KI239_10605) 2163368..2163577 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KI239_RS10610 (KI239_10610) 2163589..2163882 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KI239_RS10615 (KI239_10615) 2164048..2165531 + 1484 Protein_2066 cardiolipin synthase -
KI239_RS10620 (KI239_10620) 2165559..2166206 + 648 WP_001187630.1 HD domain-containing protein -
KI239_RS10625 (KI239_10625) 2166672..2167544 - 873 WP_000725802.1 membrane protein insertase YidC -
KI239_RS10630 (KI239_10630) 2167630..2168271 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204562 WP_000581792.1 NZ_CP076028:c2163577-2163368 [Staphylococcus sp. MZ8]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204562 NZ_CP100765:2029751-2029847 [Serratia nematodiphila]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204562 WP_000138932.1 NZ_CP076028:c2163882-2163589 [Staphylococcus sp. MZ8]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204562 NZ_CP100765:c2029847-2029707 [Serratia nematodiphila]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References