Detailed information of TA system TA204560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1989640..1990416
• Replicon: chromosome
• Accession: NZ_CP076028
• Organism: Staphylococcus sp. MZ8

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KI239_RS09620
• Protein ID: WP_000031108.1
• Coordinates: 1989640..1989792 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KI239_RS09625
• Protein ID: WP_001251224.1
• Coordinates: 1989817..1990416 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI239_RS09605 (KI239_09605)	1985777..1986598	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KI239_RS09610 (KI239_09610)	1987061..1988446	-	1386	WP_000116229.1	class II fumarate hydratase	-
KI239_RS09615 (KI239_09615)	1988642..1989037	-	396	WP_000901023.1	hypothetical protein	-
KI239_RS09620 (KI239_09620)	1989640..1989792	-	153	WP_000031108.1	SAS053 family protein	Toxin
KI239_RS09625 (KI239_09625)	1989817..1990416	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KI239_RS09630 (KI239_09630)	1990575..1991045	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KI239_RS09635 (KI239_09635)	1991050..1992177	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KI239_RS09640 (KI239_09640)	1992328..1993050	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KI239_RS09645 (KI239_09645)	1993043..1994500	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T204560 WP_000031108.1 NZ_CP076028:c1989792-1989640 [Staphylococcus sp. MZ8]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T204560 NZ_CP100765:1623126-1623434 [Serratia nematodiphila]
ATGCAGTTTACCGTATATGACAATACATATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGCCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGCTTATGCCCGG
AGATTGAGGTAAACGGCGAAAAGTTTCTCGTTATGACCCATGAGATGGCTGCCGTACGTATTTCACAGCTCGGGAAGGCC
GTTGGTAATGCCAATGAGCACAGGAATCAAATTAAAGCTGCCATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT204560 WP_001251224.1 NZ_CP076028:c1990416-1989817 [Staphylococcus sp. MZ8]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT204560 NZ_CP100765:1622881-1623123 [Serratia nematodiphila]
ATGGATATGGCAAATAACAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATC
CCTGGGCGTTAATGTGTCATCCGTATTGACAGACGCATTGAGCGTCCGTGTCAGGGATATTGAGATTCAACAGTGGCGCG
ATCAAAATCGCGAGGCGTTAGAAGAACTTAATCGCATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTT
TAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4