Detailed information of TA system TA204556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 883939..884416
• Replicon: chromosome
• Accession: NZ_CP076028
• Organism: Staphylococcus sp. MZ8

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: KI239_RS04195
• Protein ID: WP_000052076.1
• Coordinates: 883939..884127 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: KI239_RS04200
• Protein ID: WP_001059690.1
• Coordinates: 884156..884416 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KI239_RS04165 (KI239_04165)	879981..880451	+	471	WP_000824472.1	hypothetical protein	-
KI239_RS04170 (KI239_04170)	880792..881477	+	686	Protein_823	thermonuclease family protein	-
KI239_RS04175 (KI239_04175)	881834..882034	+	201	WP_001059082.1	cold-shock protein	-
KI239_RS04180 (KI239_04180)	882530..882748	-	219	WP_000005886.1	hypothetical protein	-
KI239_RS04185 (KI239_04185)	882810..883094	-	285	WP_001004401.1	hypothetical protein	-
KI239_RS04190 (KI239_04190)	883182..883751	-	570	WP_045178121.1	lipoprotein N-acylation protein LnsA	-
KI239_RS04195 (KI239_04195)	883939..884127	-	189	WP_000052076.1	hypothetical protein	Toxin
KI239_RS04200 (KI239_04200)	884156..884416	-	261	WP_001059690.1	hypothetical protein	Antitoxin
KI239_RS04205 (KI239_04205)	884757..884960	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
KI239_RS04210 (KI239_04210)	884957..885193	-	237	WP_000368687.1	hypothetical protein	-
KI239_RS04215 (KI239_04215)	885418..885999	+	582	WP_214958375.1	histidine phosphatase family protein	-
KI239_RS04220 (KI239_04220)	886072..886689	-	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
KI239_RS04225 (KI239_04225)	886844..887338	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
KI239_RS04230 (KI239_04230)	887737..888159	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
KI239_RS04235 (KI239_04235)	888307..889023	+	717	WP_000150017.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-102)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T204556 WP_000052076.1 NZ_CP076028:c884127-883939 [Staphylococcus sp. MZ8]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T204556 NZ_CP100765:c14540-14160 [Serratia nematodiphila]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATTCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTTT
GACCGAATACCACACCAATCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAGCAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGCTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAACTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTTGGCACTGACAACGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT204556 WP_001059690.1 NZ_CP076028:c884416-884156 [Staphylococcus sp. MZ8]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT204556 NZ_CP100765:c14761-14540 [Serratia nematodiphila]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGCTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGAGATGGCGTGGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56