Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2164654..2165168 Replicon chromosome
Accession NZ_CP076027
Organism Staphylococcus sp. MZ7

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KI234_RS10675 Protein ID WP_000581792.1
Coordinates 2164654..2164863 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KI234_RS10680 Protein ID WP_000138932.1
Coordinates 2164875..2165168 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KI234_RS10655 (KI234_10655) 2160162..2161520 - 1359 WP_045177762.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KI234_RS10660 (KI234_10660) 2161535..2162605 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KI234_RS10665 (KI234_10665) 2162923..2164125 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KI234_RS10670 (KI234_10670) 2164389..2164526 - 138 WP_000828354.1 Lmo0850 family protein -
KI234_RS10675 (KI234_10675) 2164654..2164863 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KI234_RS10680 (KI234_10680) 2164875..2165168 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KI234_RS10685 (KI234_10685) 2165334..2166818 + 1485 WP_000571549.1 cardiolipin synthase -
KI234_RS10690 (KI234_10690) 2166846..2167493 + 648 WP_001187630.1 HD domain-containing protein -
KI234_RS10695 (KI234_10695) 2167959..2168831 - 873 WP_000725802.1 membrane protein insertase YidC -
KI234_RS10700 (KI234_10700) 2168917..2169558 - 642 WP_000483164.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T204551 WP_000581792.1 NZ_CP076027:c2164863-2164654 [Staphylococcus sp. MZ7]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T204551 NZ_CP100764:1637452-1637769 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACGGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAACGATATCATCGA
GCAATTAAATCGCCGAGTTATGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACTCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCAGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT204551 WP_000138932.1 NZ_CP076027:c2165168-2164875 [Staphylococcus sp. MZ7]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT204551 NZ_CP100764:1637213-1637449 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGATGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTACTACGCTGAATACTGCTTTGGATGCCGAATTGCGTCAGCATGAGATGAGGAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGAAGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References